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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Woltsche, N; Valentin, K; Hoeflechner, L; Guttmann, A; Horwath-Winter, J; Schneider, MR; Ivastinovic, D; Lindner, M; Schmetterer, L; Singh, N; Riedl, R; Buchmann, A; Khalil, M; Lindner, E.
Neurofilament light chain: a new marker for neuronal decay in the anterior chamber fluid of patients with glaucoma.
Br J Ophthalmol. 2022; Doi: 10.1136/bjo-2021-320828
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Führende Autor*innen der Med Uni Graz
Lindner Ewald
Woltsche Nora
Co-Autor*innen der Med Uni Graz
Buchmann Arabella
Guttmann Andreas
Höflechner Lukas
Horwath-Winter Jutta
Ivastinovic Domagoj
Khalil Michael
Lindner Marlene
Riedl Regina
Schneider Mona Regina
Valentin Katharina
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Abstract:
BACKGROUND/AIMS: Neurofilament light chain (NfL) levels in cerebrospinal fluid and serum are reliable indicators for neuroaxonal damage in a broad spectrum of neurodegenerative diseases. Herein, we investigate NfL levels in serum and anterior chamber fluid of patients with glaucoma. METHODS: Patients scheduled for routine glaucoma or cataract surgery were recruited for this study. Retinal nerve fibre layer thickness was measured by optical coherence tomography (OCT, Heidelberg Spectralis). NfL levels in serum and in anterior chamber fluid were analysed with Simoa SR-X Analyzer (Quanterix; NFLIGHT, Lexington, Massachusetts, USA). T-test was used for parametric data and Mann-Whitney-U test for nonparametric data. Spearman's rank-order correlation was used to investigate correlations. P values<0.05 were considered as statistically significant. RESULTS: Sixty patients with glaucoma and 58 controls were enrolled. Serum NfL concentration of patients with glaucoma was similar to serum NfL concentration in controls (median (IQR); 22.7 (18.9) pg/mL vs 22.5 (24.0) pg/mL; p=0.763). A positive correlation of serum NfL with age was observed in both patients with glaucoma (r=0.77; p<0.001) and in the control group (r=0.82, p<0.001). In the anterior chamber fluid, the NfL concentration was substantially increased in patients with glaucoma compared with controls (20.7 (101.3) pg/mL vs 3.1 (2.9) pg/mL; p<0.001). Furthermore, we found a positive correlation of anterior chamber fluid NfL with preoperative intraocular pressure (r=0.39, p=0.003) and with retinal nerve fibre layer thickness (r=0.58, p<0.001). CONCLUSION: NfL levels in anterior chamber fluid are elevated in patients with glaucoma and correlate with intraocular pressure and retinal nerve fibre layer thickness. The presented data strongly support anterior chamber fluid NfL as a new marker for glaucoma.

Find related publications in this database (Keywords)
Glaucoma
Anterior chamber
Aqueous humour
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