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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Wagner-Skacel, J; Haidacher, F; Wiener, M; Pahsini, K; Marinschek, S; Lahousen, T; Wonisch, W; Bengesser, S; Butler, MI; Lackner, S; Meinitzer, A; Enko, D; Mörkl, S.
Oxidative Status in Adult Anorexia Nervosa Patients and Healthy Controls-Results from a Cross-Sectional Pilot Study.
Antioxidants (Basel). 2022; 11(5): Doi: 10.3390/antiox11050842 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Mörkl Sabrina
Wagner-Skacel Jolana
Co-Autor*innen der Med Uni Graz
Bengesser Susanne
Enko Dietmar
Haidacher Fiona Naomi Anaïs
Lackner Sonja
Lahousen-Luxenberger Theresa
Marinschek Sabine
Meinitzer Andreas
Pahsini Karoline
Wonisch Willibald
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Abstract:
Oxidative stress describes an imbalance of reactive oxygen species (ROS) and antioxidative defence systems. Recently, the consequences of oxidative stress have become a central field of research and have been linked to the genesis of multiple psychiatric diseases. Some oxidative stress parameters have not been investigated before in anorexia nervosa (AN) patients, including the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) and polyphenols (PPm). In this cross-sectional pilot study, we evaluated these markers together with total peroxides (TOC), antioxidative capacity (TAC), endogenous peroxidase activity (EPA) and antibodies against oxidized LDL (oLAb) in serum samples of 20 patients with AN compared to 20 healthy controls. The antioxidative capacity was significantly decreased in AN patients, with a mean TAC of 1.57 mmol/L (SD: ±0.62); t (34) = -2.181, p = 0.036) compared to HC (mean = 1.91 mmol/L (SD: ±0.56), while the other investigated parameters were not significantly different between the two groups. In AN patients, TAC correlated with EPA (rsp = -0.630, p = 0.009). This study suggests that there is an antioxidative deficiency in AN patients. In this respect, there is a demand for interventional studies to determine whether antioxidants can be used as add-on therapy in the treatment of AN.

Find related publications in this database (Keywords)
anorexia nervosa
oxidative stress
total oxidative capacity
total antioxidative capacity
endogenous peroxidase
antibodies against oxidized LDL
polyphenols
TMAO
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