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Pirpamer, L; Kincses, B; Kincses, ZT; Kiss, C; Damulina, A; Khalil, M; Stollberger, R; Schmidt, R; Enzinger, C; Ropele, S.
Periventricular magnetisation transfer abnormalities in early multiple sclerosis.
Neuroimage Clin. 2022; 34: 103012 Doi: 10.1016/j.nicl.2022.103012 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Enzinger Christian
Pirpamer Lukas
Co-Autor*innen der Med Uni Graz
Damulina Anna
Khalil Michael
Kiss Christian
Ropele Stefan
Schmidt Reinhold
Stollberger Rudolf

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OBJECTIVE: Recent studies suggested that CSF-mediated factors contribute to periventricular (PV) T2-hyperintense lesion formation in multiple sclerosis (MS) and this in turn correlates with cortical damage. We thus investigated if such PV-changes are observable microstructurally in early-MS and if they correlate with cortical damage. METHODS: We assessed the magnetisation transfer ratio (MTR) in PV normal-appearing white matter (NAWM) and in MS lesions in 44 patients with a clinically isolated syndrome (CIS) suggestive of MS and 73 relapsing-remitting MS (RRMS) patients. Band-wise MTR values were related to cortical mean thickness (CMT) and compared with 49 healthy controls (HCs). For each band, MTR changes were assessed relative to the average MTR values of all HCs. RESULTS: Relative to HCs, PV-MTR was significantly reduced up to 2.63% in CIS and 5.37% in RRMS (p < 0.0001). The MTR decreased towards the lateral ventricles with 0.18%/mm in CIS and 0.31%/mm in RRMS patients, relative to HCs. In RRMS, MTR-values adjacent to the ventricle and in PV-lesions correlated positively with CMT and negatively with EDSS. CONCLUSION: PV-MTR gradients are present from the earliest stage of MS, consistent with more pronounced microstructural WM-damage closer to the ventricles. The positive association between reduced CMT and lower MTR in PV-NAWM suggests a common pathophysiologic mechanism. Together, these findings indicate the potential use of multimodal MRI as refined marker for MS-related tissue changes.
Find related publications in this database (using NLM MeSH Indexing)
Brain - administration & dosage
Cerebral Ventricles - pathology
Demyelinating Diseases - pathology
Humans - administration & dosage
Magnetic Resonance Imaging - administration & dosage
Multiple Sclerosis - diagnostic imaging, pathology
Multiple Sclerosis, Relapsing-Remitting - pathology
White Matter - pathology

Find related publications in this database (Keywords)
Normal-appearing white matter
Magnetisation transfer ratio
Periventricular gradient
Cortical thinning
Multiple sclerosis
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