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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Trummer, O; Foessl, I; Schweighofer, N; Arifi, E; Haudum, CW; Reintar, S; Pilz, S; Theiler-Schwetz, V; Trummer, C; Zirlik, A; Schmidt, A; Colantonio, C; Kolesnik, E; Verheyen, N; Pieber, TR; Obermayer-Pietsch, B.
Expression Profiles of miR-22-5p and miR-142-3p Indicate Hashimoto's Disease and Are related to Thyroid Antibodies.
Genes (Basel). 2022; 13(2): Doi: 10.3390/genes13020171 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Fößl Ines
Trummer Olivia
Co-Autor*innen der Med Uni Graz
Colantonio Caterina
Haudum Christoph
Kolesnik Ewald
Obermayer-Pietsch Barbara
Pieber Thomas
Pilz Stefan
Reintar Sharmaine
Schmidt Albrecht
Schweighofer Natascha
Theiler-Schwetz Verena
Trummer Christian
Verheyen Nicolas Dominik
Zirlik Andreas
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Abstract:
Hashimoto's thyroiditis (HT) is the most prevalent autoimmune disorder of the thyroid (AITD) and characterized by the presence of circulating autoantibodies evoked by a, to date, not fully understood dysregulation of the immune system. Autoreactive lymphocytes and inflammatory processes in the thyroid gland can impair or enhance thyroid hormone secretion. MicroRNAs (miRNAs) are small noncoding RNAs, which can play a pivotal role in immune functions and the development of autoimmunity. The aim of the present study was to evaluate whether the expression of 9 selected miRNAs related to immunological functions differ in patients with HT compared to healthy controls. MiRNA profiles were analysed using quantitative reverse transcription polymerase chain reaction (qRT-PCR) in 24 patients with HT and 17 healthy controls. Systemic expressions of miR-21-5p, miR-22-3p, miR-22-5p, miR-142-3p, miR-146a-5p, miR-301-3p and miR-451 were significantly upregulated in patients with HT (p ≤ 0.01) and were suitable to discriminate between HT and healthy controls in AUC analysis. Altered expressions of miR-22-5p and miR-142-3p were associated with higher levels of thyroid antibodies, suggesting their contribution to the pathogenesis of HT.
Find related publications in this database (using NLM MeSH Indexing)
Autoantibodies - administration & dosage
Autoimmunity - administration & dosage
Hashimoto Disease - genetics
Humans - administration & dosage
MicroRNAs - genetics

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