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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Aziz, F; Aberer, F; Bräuer, A; Ciardi, C; Clodi, M; Fasching, P; Karolyi, M; Kautzky-Willer, A; Klammer, C; Malle, O; Pawelka, E; Pieber, T; Peric, S; Ress, C; Schranz, M; Sourij, C; Stechemesser, L; Stingl, H; Stöcher, H; Stulnig, T; Tripolt, N; Wagner, M; Wolf, P; Zitterl, A; Reisinger, AC; Siller-Matula, J; Hummer, M; Moser, O; von-Lewinski, D; Eller, P; Kaser, S; Sourij, H.
COVID-19 In-Hospital Mortality in People with Diabetes Is Driven by Comorbidities and Age-Propensity Score-Matched Analysis of Austrian National Public Health Institute Data.
Viruses. 2021; 13(12): Doi: 10.3390/v13122401 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Aziz Faisal
Sourij Harald
Co-Autor*innen der Med Uni Graz
Aberer Felix
Eller Philipp
Malle Oliver
Pieber Thomas
Reisinger Alexander Christian
Sourij Caren
Tripolt Norbert

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BACKGROUND: It is a matter of debate whether diabetes alone or its associated comorbidities are responsible for severe COVID-19 outcomes. This study assessed the impact of diabetes on intensive care unit (ICU) admission and in-hospital mortality in hospitalized COVID-19 patients. METHODS: A retrospective analysis was performed on a countrywide cohort of 40,632 COVID-19 patients hospitalized between March 2020 and March 2021. Data were provided by the Austrian data platform. The association of diabetes with outcomes was assessed using unmatched and propensity-score matched (PSM) logistic regression. RESULTS: 12.2% of patients had diabetes, 14.5% were admitted to the ICU, and 16.2% died in the hospital. Unmatched logistic regression analysis showed a significant association of diabetes (odds ratio [OR]: 1.24, 95% confidence interval [CI]: 1.15-1.34, p < 0.001) with in-hospital mortality, whereas PSM analysis showed no significant association of diabetes with in-hospital mortality (OR: 1.08, 95%CI: 0.97-1.19, p = 0.146). Diabetes was associated with higher odds of ICU admissions in both unmatched (OR: 1.36, 95%CI: 1.25-1.47, p < 0.001) and PSM analysis (OR: 1.15, 95%CI: 1.04-1.28, p = 0.009). CONCLUSIONS: People with diabetes were more likely to be admitted to ICU compared to those without diabetes. However, advanced age and comorbidities rather than diabetes itself were associated with increased in-hospital mortality in COVID-19 patients.
Find related publications in this database (using NLM MeSH Indexing)
Adult - administration & dosage
Aged - administration & dosage
Aged, 80 and over - administration & dosage
Austria - epidemiology
COVID-19 - mortality
Cohort Studies - administration & dosage
Comorbidity - administration & dosage
Diabetes Mellitus - epidemiology
Female - administration & dosage
Hospital Mortality - administration & dosage
Hospitalization - administration & dosage
Humans - administration & dosage
Intensive Care Units - administration & dosage
Male - administration & dosage
Middle Aged - administration & dosage
Odds Ratio - administration & dosage
Propensity Score - administration & dosage
Public Health - administration & dosage
Retrospective Studies - administration & dosage
Risk Factors - administration & dosage
SARS-CoV-2 - administration & dosage
Young Adult - administration & dosage

Find related publications in this database (Keywords)
intensive care
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