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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Raab, P; Ropele, S; Bültmann, E; Salcher, R; Lanfermann, H; Wattjes, MP.
Analysis of deep grey nuclei susceptibility in early childhood: a quantitative susceptibility mapping and R2* study at 3 Tesla.
Neuroradiology. 2022; 64(5):1021-1031 Doi: 10.1007/s00234-021-02846-0 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz
Ropele Stefan

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PURPOSE: Aging is the most significant determinant for brain iron accumulation in the deep grey matter. Data on brain iron evolution during brain maturation in early childhood are limited. The purpose of this study was to investigate age-related iron deposition in the deep grey matter in children using quantitative susceptibility (QSM) and R2* mapping. METHODS: We evaluated brain MRI scans of 74 children (age 6-154 months, mean 40 months). A multi-echo gradient-echo sequence obtained at 3 Tesla was used for the QSM and R2* calculation. Susceptibility of the pallidum, head of caudate nucleus, and putamen was correlated with age and compared between sexes. RESULTS: Susceptibility changes in all three nuclei correlated with age (correlation coefficients for QSM/R2*: globus pallidus 0.955/0.882, caudate nucleus 0.76/0.65, and putamen 0.643/0.611). During the first 2 years, the R2* values increased more rapidly than the QSM values, indicating a combined effect of iron deposition and myelination, followed by a likely dominating effect of iron deposition. There was no significant gender difference. CONCLUSION: QSM and R2* can monitor myelin maturation processes and iron accumulation in the deep grey nuclei of the brain in early life and may be a promising tool for the detection of deviations of this normal process. Susceptibility in the deep nuclei is almost similar early after birth and increases more quickly in the pallidum. The combined use of QSM and R2* analysis is beneficial.
Find related publications in this database (using NLM MeSH Indexing)
Brain - administration & dosage
Brain Mapping - administration & dosage
Child - administration & dosage
Child, Preschool - administration & dosage
Gray Matter - diagnostic imaging
Humans - administration & dosage
Iron - administration & dosage
Magnetic Resonance Imaging - administration & dosage

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