Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tulchiner, G; Staudacher, N; Fritz, J; Hackl, M; Pichler, M; Seles, M; Shariat, SF; D'Andrea, D; Gust, K; Albrecht, W; Grubmüller, K; Madersbacher, S; Graf, S; Lusuardi, L; Augustin, H; Berger, A; Loidl, W; Horninger, W; Pichler, R.
Seasonal Variations in the Diagnosis of Testicular Germ Cell Tumors: A National Cancer Registry Study in Austria.
Cancers (Basel). 2021; 13(21):
Doi: 10.3390/cancers13215377
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- Co-Autor*innen der Med Uni Graz
- Augustin Herbert
- Pichler Martin
- Seles Maximilian
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- Abstract:
- We conducted a retrospective National Cancer Registry study in Austria to assess a possible seasonal variation in the clinical diagnosis of testicular germ cell tumors (TGCT). In total, 3615 testicular cancer diagnoses were identified during an 11-year period from 2008 to 2018. Rate ratios for the monthly number of TGCT diagnoses, as well as of seasons and half-years, were assessed using a quasi-Poisson model. We identified, for the first time, a statistically significant seasonal trend (p < 0.001) in the frequency of monthly newly diagnosed cases of TGCT. In detail, clear seasonal variations with a reduction in the tumor incidence during the summer months (Apr-Sep) and an increase during the winter months (Oct-Mar) were observed (p < 0.001). Focusing on seasonality, the incidence during the months of Oct-Dec (p = 0.008) and Jan-Mar (p < 0.001) was significantly higher compared to the months of Jul-Sep, respectively. Regarding histopathological features, there is a predominating incidence in the winter months compared to summer months, mainly concerning pure seminomas (p < 0.001), but not the non-seminoma or mixed TGCT groups. In conclusion, the incidence of TGCT diagnoses in Austria has a strong seasonal pattern, with the highest rate during the winter months. These findings may be explained by a delay of self-referral during the summer months. However, the hypothetical influence of vitamin D3 in testicular carcinogenesis underlying seasonal changes in TGCT diagnosis should be the focus of further research.
- Find related publications in this database (Keywords)
- detection
- diagnosis
- seasonal variation
- testicular cancer
- vitamin D
- screening
- incidence
- germ cell tumors