Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Höller, V; Seebacher, H; Zach, D; Schwegel, N; Ablasser, K; Kolesnik, E; Gollmer, J; Waltl, G; Rainer, PP; Verheyen, S; Zirlik, A; Verheyen, N.
Myocardial Deformation Analysis in MYBPC3 and MYH7 Related Sarcomeric Hypertrophic Cardiomyopathy-The Graz Hypertrophic Cardiomyopathy Registry.
Genes (Basel). 2021; 12(10): Doi: 10.3390/genes12101469 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Höller Viktoria
Tichy Heidelis Anna
Verheyen Nicolas Dominik
Co-Autor*innen der Med Uni Graz
Ablasser Klemens
Gollmer Johannes
Kolesnik Ewald
Rainer Peter
Verheyen Sarah
Zach David
Zirlik Andreas

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Accumulating evidence suggests that individuals with sarcomeric hypertrophic cardiomyopathy (HCM) carrying MYH7 mutations may have a worse prognosis than MYBPC3 mutation carriers. Myocardial deformation analysis is superior to standard echocardiography in detecting subtle myocardial dysfunction and scar formation, but studies evaluating the association with HCM genotype are scarce. We therefore aimed to compare myocardial strain parameters between MYBPC3 and MYH7 mutation carriers with proven HCM. Participants of the prospective Graz HCM Registry carrying at least one causative mutation in MYBPC3 (n = 39) or MYH7 (n = 18) were enrolled. MYBPC3 mutation carriers were older, predominantly male and more often treated with an implantable cardioverter-defibrillator (39% vs. 0%; p = 0.002). Using analyses of covariance, there were no significant differences between MYBPC3 and MYH7 mutation carriers with regard to left ventricular global longitudinal strain (estimated marginal means ± standard deviation: -16.9 ± 0.6% vs. -17.3 ± 0.9%; p = 0.807) and right ventricular 6-segments endocardial strain (-24.3 ± 1.0% vs. 26.3 ± 1.5%; p = 0.285). Our study suggests, that myocardial deformation analysis may not be helpful in concluding on the underlying HCM genotype, and vice versa.
Find related publications in this database (using NLM MeSH Indexing)
Adult - administration & dosage
Cardiac Myosins - genetics
Cardiomyopathy, Hypertrophic - diagnosis, genetics, pathology
Carrier Proteins - genetics
Echocardiography - administration & dosage
Female - administration & dosage
Genetic Association Studies - administration & dosage
Genetic Predisposition to Disease - administration & dosage
Genotype - administration & dosage
Heart - diagnostic imaging, physiopathology
Heart Ventricles - pathology
Humans - administration & dosage
Male - administration & dosage
Middle Aged - administration & dosage
Mutation - genetics
Myocardium - metabolism, pathology
Myosin Heavy Chains - genetics
Phenotype - administration & dosage
Prognosis - administration & dosage
Registries - administration & dosage
Sarcomeres - genetics, pathology

Find related publications in this database (Keywords)
hypertrophic cardiomyopathy
speckle tracking
myocardial deformation analysis
longitudinal strain
© Med Uni Graz Impressum