Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Höller, V; Seebacher, H; Zach, D; Schwegel, N; Ablasser, K; Kolesnik, E; Gollmer, J; Waltl, G; Rainer, PP; Verheyen, S; Zirlik, A; Verheyen, N.
Myocardial Deformation Analysis in MYBPC3 and MYH7 Related Sarcomeric Hypertrophic Cardiomyopathy-The Graz Hypertrophic Cardiomyopathy Registry.
Genes (Basel). 2021; 12(10):
Doi: 10.3390/genes12101469
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Höller Viktoria
- Tichy Heidelis Anna
- Verheyen Nicolas Dominik
- Co-Autor*innen der Med Uni Graz
- Ablasser Klemens
- Gollmer Johannes
- Kolesnik Ewald
- Rainer Peter
- Verheyen Sarah
- Zach David
- Zirlik Andreas
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Accumulating evidence suggests that individuals with sarcomeric hypertrophic cardiomyopathy (HCM) carrying MYH7 mutations may have a worse prognosis than MYBPC3 mutation carriers. Myocardial deformation analysis is superior to standard echocardiography in detecting subtle myocardial dysfunction and scar formation, but studies evaluating the association with HCM genotype are scarce. We therefore aimed to compare myocardial strain parameters between MYBPC3 and MYH7 mutation carriers with proven HCM. Participants of the prospective Graz HCM Registry carrying at least one causative mutation in MYBPC3 (n = 39) or MYH7 (n = 18) were enrolled. MYBPC3 mutation carriers were older, predominantly male and more often treated with an implantable cardioverter-defibrillator (39% vs. 0%; p = 0.002). Using analyses of covariance, there were no significant differences between MYBPC3 and MYH7 mutation carriers with regard to left ventricular global longitudinal strain (estimated marginal means ± standard deviation: -16.9 ± 0.6% vs. -17.3 ± 0.9%; p = 0.807) and right ventricular 6-segments endocardial strain (-24.3 ± 1.0% vs. 26.3 ± 1.5%; p = 0.285). Our study suggests, that myocardial deformation analysis may not be helpful in concluding on the underlying HCM genotype, and vice versa.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Cardiac Myosins - genetics
- Cardiomyopathy, Hypertrophic - diagnosis, genetics, pathology
- Carrier Proteins - genetics
- Echocardiography - administration & dosage
- Female - administration & dosage
- Genetic Association Studies - administration & dosage
- Genetic Predisposition to Disease - administration & dosage
- Genotype - administration & dosage
- Heart - diagnostic imaging, physiopathology
- Heart Ventricles - pathology
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Mutation - genetics
- Myocardium - metabolism, pathology
- Myosin Heavy Chains - genetics
- Phenotype - administration & dosage
- Prognosis - administration & dosage
- Registries - administration & dosage
- Sarcomeres - genetics, pathology
- Find related publications in this database (Keywords)
- hypertrophic cardiomyopathy
- MYBPC3
- MYH7
- genotype-phenotype
- speckle tracking
- myocardial deformation analysis
- longitudinal strain
- echocardiography