Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gibb, AA; Murray, EK; Eaton, DM; Huynh, AT; Tomar, D; Garbincius, JF; Kolmetzky, DW; Berretta, RM; Wallner, M; Houser, SR; Elrod, JW.
Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model.
JACC Basic Transl Sci. 2021; 6(8):650-672
Doi: 10.1016/j.jacbts.2021.07.004
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- Abstract:
- In this study the authors used systems biology to define progressive changes in metabolism and transcription in a large animal model of heart failure with preserved ejection fraction (HFpEF). Transcriptomic analysis of cardiac tissue, 1-month post-banding, revealed loss of electron transport chain components, and this was supported by changes in metabolism and mitochondrial function, altogether signifying alterations in oxidative metabolism. Established HFpEF, 4 months post-banding, resulted in changes in intermediary metabolism with normalized mitochondrial function. Mitochondrial dysfunction and energetic deficiencies were noted in skeletal muscle at early and late phases of disease, suggesting cardiac-derived signaling contributes to peripheral tissue maladaptation in HFpEF. Collectively, these results provide insights into the cellular biology underlying HFpEF progression.
- Find related publications in this database (Keywords)
- heart failure
- mitochondria
- metabolomics
- preserved ejection fraction
- systems biology
- transcriptomics