Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Rech, L; Rainer, PP.
The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases - A Mini Review.
Front Cardiovasc Med. 2021; 8: 715903 Doi: 10.3389/fcvm.2021.715903 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Rainer Peter
Rech Cara Lavinia Shirin

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Inflammation plays a central role in cardiovascular diseases (CVD). One pathway under investigation is the innate immune DNA sensor cyclic GMP-AMP synthase (cGAS) and its downstream receptor stimulator of interferon genes (STING). cGAS-STING upregulates type I interferons in response to pathogens. Recent studies show that also self-DNA may activate cGAS-STING, for instance, DNA released from nuclei or mitochondria during obesity or myocardial infarction. Here, we focus on emerging evidence describing the interaction of cGAS-STING with cardiovascular risk factors and disease. We also touch on translational therapeutic opportunities and potential further investigations.

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