Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rech, L; Rainer, PP.
The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases - A Mini Review.
Front Cardiovasc Med. 2021; 8: 715903
Doi: 10.3389/fcvm.2021.715903
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- Führende Autor*innen der Med Uni Graz
- Rainer Peter
- Rech Cara Lavinia Shirin
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- Abstract:
- Inflammation plays a central role in cardiovascular diseases (CVD). One pathway under investigation is the innate immune DNA sensor cyclic GMP-AMP synthase (cGAS) and its downstream receptor stimulator of interferon genes (STING). cGAS-STING upregulates type I interferons in response to pathogens. Recent studies show that also self-DNA may activate cGAS-STING, for instance, DNA released from nuclei or mitochondria during obesity or myocardial infarction. Here, we focus on emerging evidence describing the interaction of cGAS-STING with cardiovascular risk factors and disease. We also touch on translational therapeutic opportunities and potential further investigations.
- Find related publications in this database (Keywords)
- STING
- interferon
- DAMPs
- cardiovascular
- inflammation
- cGAS