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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Moser, O; Eckstein, ML; Mueller, A; Tripolt, NJ; Yildirim, H; Abbas, F; Pferschy, PN; Goswami, N; Aberer, F; Obermayer, A; Pieber, TR; Kojzar, H; Sourij, C; Brunner, M; Niedrist, T; Herrmann, M; Sourij, H.
Impact of a Single 36 Hours Prolonged Fasting Period in Adults With Type 1 Diabetes - A Cross-Over Controlled Trial.
FRONT ENDOCRINOL. 2021; 12: 656346 Doi: 10.3389/fendo.2021.656346 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Moser Othmar
Sourij Harald
Co-Autor*innen der Med Uni Graz
Abbas Farah
Aberer Felix
Brunner Martina
Eckstein Max Lennart
Goswami Nandu
Herrmann Markus
Kojzar Harald
Müller Alexander
Niedrist Tobias
Obermayer Anna Maria Antonia
Pferschy Peter
Pieber Thomas
Sourij Caren
Tripolt Norbert

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Prolonged fasting has shown beneficial effects in healthy individuals and in people with chronic diseases. In type 1 diabetes, the effect or even the feasibility of fasting is unclear. We aimed to assess the impact and safety of prolonged fasting in adults with type 1 diabetes. Glycemia was assessed during overnight fasting (12 hours) vs. prolonged fasting (36 hours) via an intermittently-scanned continuous glucose monitoring system. Anthropometric data, metabolic and hormonal markers were compared between both trial arms. After each fasting period, a 75 g oral glucose tolerance test was performed and plasma glucose levels and hormones were assessed. Data were compared via paired t-tests and mixed-model regressions (p ≤ 0.05). Twenty individuals with type 1 diabetes (7 females) with a mean ± SD age of 35 ± 11 years, body mass index (BMI) 24.8 ± 2.8 kg/m2 and HbA1c 54 ± 7 mmol/mol were included. Hypoglycemia/hour (70 mg/dL; <3.9 mmol/L) was similar in both trial arms (12 hrs: 0.07 ± 0.06 vs. 36 hrs: 0.05 ± 0.03, p=0.21). Glycemic excursions during the oral glucose tolerance test were not different after the two fasting periods. Beta-hydroxybutyrate levels were higher after prolonged fasting (p=0.0006). Our study showed that people with type 1 diabetes can safely perform a 36 hours fasting period with a low risk of hypoglycemia and ketoacidosis. Clinical Trial Registration:, identifier DRKS00016148.

Find related publications in this database (Keywords)
type 1 diabetes
OGTT (oral glucose tolerance test)
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