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von, Lewinski, D; Benedikt, M; Tripolt, N; Wallner, M; Sourij, H; Kolesnik, E.
Can sodium-glucose cotransporter 2 inhibitors be beneficial in patients with acute myocardial infarction?
Kardiol Pol. 2021; 79(5):503-509 Doi: 10.33963/KP.15969 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
von Lewinski Dirk
Co-Autor*innen der Med Uni Graz
Benedikt Martin
Kolesnik Ewald
Sourij Harald
Tripolt Norbert
Wallner Markus

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The sodium-glucose cotransporter 2 inhibitors (SGLT2i), empagliflozin, dapagliflozin, and canagliflozin, have shown impressive beneficial effects in patients with type 2 diabetes mellitus in mandatory cardiovascular outcome trials. Retrospective data analysis revealed signals that pointed towards positive effects independent of the antidiabetic effects. This could be confirmed for empagliflozin and dapagliflozin in chronic heart failure with reduced ejection fraction alone, where rates of hospitalization for heart failure and cumulative major adverse cardiovascular events were reduced to a similar extent in patients with and without diabetes mellitus as in corresponding outcome trials. Cardiac remodeling following myocardial infarction leads to heart failure with reduced ejection fraction in many patients and aggravates morbidity and mortality. Clinical data of SGLT2i treatment after acute myocardial infarction is sparse. This review focuses on available experimental data on the effects of SGLT2i used before, during, and after myocardial infarction as well as already published and currently ongoing clinical trials.
Find related publications in this database (using NLM MeSH Indexing)
Cardiovascular Diseases - administration & dosage
Diabetes Mellitus, Type 2 - complications, drug therapy
Glucose - administration & dosage
Humans - administration & dosage
Myocardial Infarction - drug therapy
Retrospective Studies - administration & dosage
Sodium - administration & dosage
Sodium-Glucose Transporter 2 Inhibitors - therapeutic use

Find related publications in this database (Keywords)
sodium-glucose cotransporter 2 inhibitors
myocardial infarction
clinical trials
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