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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Hatzl, S; Posch, F; Sareban, N; Stradner, M; Rosskopf, K; Reisinger, AC; Eller, P; Schörghuber, M; Toller, W; Sloup, Z; Prüller, F; Gütl, K; Pilz, S; Rosenkranz, AR; Greinix, HT; Krause, R; Schlenke, P; Schilcher, G.
Convalescent plasma therapy and mortality in COVID-19 patients admitted to the ICU: a prospective observational study.
Ann Intensive Care. 2021; 11(1): 73 Doi: 10.1186/s13613-021-00867-9 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Hatzl Stefan
Krause Robert
Co-Autor*innen der Med Uni Graz
Eller Philipp
Greinix Hildegard
Gütl Katharina
Pilz Stefan
Posch Florian
Prüller Florian
Reisinger Alexander Christian
Rosenkranz Alexander
Rosskopf Konrad
Sareban Nazanin
Schilcher Gernot
Schlenke Peter
Schörghuber Michael
Sloup Zdenka
Stradner Martin Helmut
Toller Wolfgang

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BACKGROUND: This study aimed to quantify the potential survival benefit of convalescent plasma therapy (CVP) in critically ill patients with acute respiratory failure related to coronavirus disease-2019 (COVID-19). METHODS: This is a single-center prospective observational cohort study in COVID-19 patients with acute respiratory failure. Immediately after intensive care unit (ICU) admission patients were allocated to CVP treatment following pre-specified criteria to rapidly identify those patients potentially susceptible for this treatment. A propensity score adjustment [inverse probability of treatment weighted (IPTW) analysis] was implemented to account rigorously for imbalances in prognostic variables between the treatment groups. RESULTS: We included 120 patients of whom 48 received CVP. Thirty percent were female with a median age of 66 years [25th-75th percentile 54-75]. Eighty-eight percent of patients presented with severe acute respiratory failure as displayed by a median paO2/FiO2 ratio (Horowitz Index) of 92 [77-150]. All patients required any kind of ventilatory support with more than half of them (52%) receiving invasive ventilation. Thirty-day ICU overall survival (OS) was 69% in the CVP group and 54% in the non-CVP group (log-rank p = 0.049), respectively. After weighing the time-to-event data for the IPTW, the favorable association between CVP and OS became even stronger (log-rank p = 0.035). Moreover, an exploratory analysis showed an overall survival benefit of CVP therapy for patients with non-invasive ventilation (Hazard ratio 0.12 95% CI 0.03-0.57, p = 0.007) CONCLUSION: Administration of CVP in patients with acute respiratory failure related to COVID-19 is associated with improved ICU survival rates.

Find related publications in this database (Keywords)
Intensive care
Convalescent plasma
Respiratory failure
Acute respiratory distress syndrome
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