Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Balihodzic, A; Barth, DA; Prinz, F; Pichler, M.
Involvement of Long Non-Coding RNAs in Glucose Metabolism in Cancer.
Cancers (Basel). 2021; 13(5): 977
Doi: 10.3390/cancers13050977
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- Führende Autor*innen der Med Uni Graz
- Balihodzic Amar
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Barth Dominik Andreas
- Prinz Felix
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- Abstract:
- The rapid and uncontrolled proliferation of cancer cells is supported by metabolic reprogramming. Altered glucose metabolism supports cancer growth and progression. Compared with normal cells, cancer cells show increased glucose uptake, aerobic glycolysis and lactate production. Byproducts of adjusted glucose metabolism provide additional benefits supporting hallmark capabilities of cancer cells. Long non-coding RNAs (lncRNAs) are a heterogeneous group of transcripts of more than 200 nucleotides in length. They regulate numerous cellular processes, primarily through physical interaction with other molecules. Dysregulated lncRNAs are involved in all hallmarks of cancer including metabolic alterations. They may upregulate metabolic enzymes, modulate the expression of oncogenic or tumor-suppressive genes and disturb metabolic signaling pathways favoring cancer progression. Thus, lncRNAs are not only potential clinical biomarkers for cancer diagnostics and prediction but also possible therapeutic targets. This review summarizes the lncRNAs involved in cancer glucose metabolism and highlights their underlying molecular mechanisms.
- Find related publications in this database (Keywords)
- long non-coding RNA
- lncRNA
- cancer
- glucose metabolism