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Scheipner, L; Smolle, MA; Barth, D; Posch, F; Stotz, M; Pichler, M; StÖger, H; Gerger, A; Riedl, JM.
The AST/ALT Ratio Is an Independent Prognostic Marker for Disease-free Survival in Stage II and III Colorectal Carcinoma.
Anticancer Res. 2021; 41(1):429-436 Doi: 10.21873/anticanres.14792
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Führende Autor*innen der Med Uni Graz
Gerger Armin
Scheipner Lukas
Co-Autor*innen der Med Uni Graz
Barth Dominik Andreas
Pichler Martin
Posch Florian
Riedl Jakob
Smolle Maria Anna
Stöger Herbert
Stotz Michael

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The Aspartate aminotransaminase/Alanine aminotransaminase ratio (AST/ALT ratio) has been identified as a prognostic marker for several malignancies. In this study, we evaluated the prognostic value of the AST/ALT ratio in a large cohort of non-metastatic colorectal cancer patients (CRC). A total of 536 patients with stage II and III CRC, as well as available AST/ALT ratio were included in this single-center retrospective analysis. Laboratory data were measured within two weeks before histological tumor diagnosis. Co-Primary endpoints for this analysis were disease-free survival (DFS) and overall survival (OS). In univariate cox regression DFS was significantly shorter in patients with an elevated AST/ALT ratio (HR=1.568, 95%CI=1.10-2.23, p=0.012). In multivariable analysis, the prognostic association between an elevated AST/ALT ratio and a poor survival prevailed statistically significant (HR=1.53, 95%C=1.05-2.22, p=0.026). No statistically significant association between the AST/ALT ratio and OS was observed (HR=1.4, 95% CI=0.89-2.22, p=0.14). In this study, the serum AST/ALT ratio emerged as a valid prognostic marker for DFS in non-metastatic colorectal cancer patients at stage II and III. Copyright© 2021, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Alanine Transaminase - blood
Aspartate Aminotransferases - blood
Biomarkers, Tumor -
Colorectal Neoplasms - blood
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - mortality
Colorectal Neoplasms - therapy
Female -
Humans -
Male -
Middle Aged -
Neoplasm Grading -
Neoplasm Metastasis -
Neoplasm Staging -
Prognosis -
Proportional Hazards Models -
Retrospective Studies -
Treatment Outcome -

Find related publications in this database (Keywords)
Colorectal cancer
AST/ALT ratio
disease free survival
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