Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lackner, A; Tiefenthaler, V; Mirzayeva, J; Posch, F; Rossmann, C; Kastrati, K; Radner, H; Demel, U; Gretler, J; Stotz, M; Graninger, WB; Stradner, MH.
The use and diagnostic value of testing myositis-specific and myositis-associated autoantibodies by line immuno-assay: a retrospective study.
Ther Adv Musculoskelet Dis. 2020; 12: 1759720X20975907-1759720X20975907.
Doi: 10.1177/1759720X20975907
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- Führende Autor*innen der Med Uni Graz
- Lackner Angelika
- Stradner Martin Helmut
- Co-Autor*innen der Med Uni Graz
- Demel Ulrike
- Graninger Winfried
- Gretler Judith
- Posch Florian
- Roßmann Christopher Herbert
- Stotz Michael
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- Abstract:
- Line immune-assays (LIA) for the detection of myositis-specific antibodies (MSA) are used widely for characterization of idiopathic inflammatory myopathies (IIM). Their current use and significance for the diagnosis of IIM remains unclear. In this retrospective analysis, we retrieved clinical diagnoses of patients tested for MSA and myositis-associated antibodies (MAA) Jo-1, Mi-2α, Mi-2β, TIF1γ, SRP, MDA-5, NXP-2, SAE, PL-7, PL-12, EJ, OJ, PM-Scl100, PM-Scl75 and Ku. We calculated clinical specificity, clinical sensitivity, negative- and positive predictive values (PPV) as well as positive and negative likelihood ratios. In total, we analyzed 3167 samples. After exclusion of repeated measurements and patients with insufficient clinical information, data of 1118 patients were available for analysis. A total of 242 patients tested positive for at least one antibody, of which 45 patients had a diagnosis of IIM; 25 IIM patients were negative for all MSA/MAA. Clinical specificity of MSA/MAA for the diagnosis of IIM ranged between 94.2% and 99.9%. Clinical sensitivity and PPV across all antibodies tested ranged from 0.0% to 12.9% and 0.0% to 72.7%, respectively. In clinical practice MSA/MAA are used widely for diagnostic work-up of IIM, resulting in a low pre-test probability. Clinicians should be aware that PPVs for most MSA/MAA are low. © The Author(s), 2020.
- Find related publications in this database (Keywords)
- auto-antibody
- idiopathic inflammatory myopathy
- line-immune assay
- myositis-specific antibody