Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jud, P; Verheyen, N; Dejaco, C; Haas, E; Szolar, D; Meinitzer, A; Duftner, C; Thonhofer, R; Gressenberger, P; Brodmann, M; Hafner, F.
Prevalence and prognostic factors for aortic dilatation in giant cell arteritis - a longitudinal study.
Semin Arthritis Rheum. 2021; 51(4):911-918
Doi: 10.1016/j.semarthrit.2020.11.003
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- Führende Autor*innen der Med Uni Graz
- Jud Philipp
- Co-Autor*innen der Med Uni Graz
- Brodmann Marianne
- Dejaco Christian
- Gressenberger Paul Georg
- Haas Elke
- Hafner Franz
- Meinitzer Andreas
- Verheyen Nicolas Dominik
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- Abstract:
- OBJECTIVES: Predictive data for the development of aortic dilatation (AD) in giant-cell arteritis (GCA) are controversial. The aim was to investigate by computed tomography (CT) the prevalence of AD in a consecutive cohort of GCA patients and controls, and to identify possible predictors for AD. METHODS: GCA patients and controls were identified by electronic search and underwent aortic contrast enhanced CT defining AD by aortic diameter adjusted to age, gender and body surface area. Pulse-wave velocity, intima-media thickness (IMT) and laboratory studies including lymphocyte subsets were conducted identifying potential factors associated with AD. Clinical and laboratory parameters at disease onset, occurrence of aortic rupture/dissection before and up to five years after study visit were retrieved by chart review. RESULTS: 144 GCA patients and 115 controls were included. GCA patients developed more frequently AD of the ascending and thoracic descending aorta compared to controls (OR 2.60, p = 0.016; OR 3.65, p = 0.005, respectively). Factors associated with AD development of thoracic descending aorta, but not of the ascending aorta, were higher percentages of circulating CD3+CD4+ cells, higher CD4/CD8 ratio, presence of polymyalgia rheumatica and increased carotid IMT at disease onset (OR range 1.10-3.11, all with p < 0.05). During follow-up, no GCA patient required surgical aortic repair or suffered aortic rupture/dissection. CONCLUSIONS: Thoracic but not abdominal ADs occur more commonly in GCA patients, however, the subsequent risk for aortic repair, rupture or dissection is low. Changes of T-cell subsets, presence of polymyalgia rheumatica and increased carotid IMT at disease onset are associated with AD development.
- Find related publications in this database (Keywords)
- Giant cell arteritis
- Vasculitis
- Lymphocytes
- Inflammation
- Endothelium