Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sourij, H; Aziz, F; Bräuer, A; Ciardi, C; Clodi, M; Fasching, P; Karolyi, M; Kautzky-Willer, A; Klammer, C; Malle, O; Oulhaj, A; Pawelka, E; Peric, S; Ress, C; Sourij, C; Stechemesser, L; Stingl, H; Stulnig, T; Tripolt, N; Wagner, M; Wolf, P; Zitterl, A; Kaser, S, , COVID-19, in, diabetes, in, Austria, study, group.
COVID-19 fatality prediction in people with diabetes and prediabetes using a simple score upon hospital admission.
Diabetes Obes Metab. 2021; 23(2):589-598
Doi: 10.1111/dom.14256
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- Führende Autor*innen der Med Uni Graz
- Sourij Harald
- Co-Autor*innen der Med Uni Graz
- Aziz Faisal
- Malle Oliver
- Sourij Caren
- Tripolt Norbert
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- Abstract:
- AIM: To assess predictors of in-hospital mortality in people with prediabetes and diabetes hospitalized for COVID-19 infection and to develop a risk score for identifying those at the greatest risk of a fatal outcome. MATERIALS AND METHODS: A combined prospective and retrospective, multicentre, cohort study was conducted at 10 sites in Austria in 247 people with diabetes or newly diagnosed prediabetes who were hospitalized with COVID-19. The primary outcome was in-hospital mortality and the predictor variables upon admission included clinical data, co-morbidities of diabetes or laboratory data. Logistic regression analyses were performed to identify significant predictors and to develop a risk score for in-hospital mortality. RESULTS: The mean age of people hospitalized (n = 238) for COVID-19 was 71.1 ± 12.9 years, 63.6% were males, 75.6% had type 2 diabetes, 4.6% had type 1 diabetes and 19.8% had prediabetes. The mean duration of hospital stay was 18 ± 16 days, 23.9% required ventilation therapy and 24.4% died in the hospital. The mortality rate in people with diabetes was numerically higher (26.7%) compared with those with prediabetes (14.9%) but without statistical significance (P = .128). A score including age, arterial occlusive disease, C-reactive protein, estimated glomerular filtration rate and aspartate aminotransferase levels at admission predicted in-hospital mortality with a C-statistic of 0.889 (95% CI: 0.837-0.941) and calibration of 1.000 (P = .909). CONCLUSIONS: The in-hospital mortality for COVID-19 was high in people with diabetes but not significantly different to the risk in people with prediabetes. A risk score using five routinely available patient variables showed excellent predictive performance for assessing in-hospital mortality.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Austria - administration & dosage
- COVID-19 - mortality, virology
- Diabetes Mellitus, Type 2 - mortality, virology
- Female - administration & dosage
- Health Status Indicators - administration & dosage
- Hospital Mortality - administration & dosage
- Hospitals - administration & dosage
- Humans - administration & dosage
- Length of Stay - statistics & numerical data
- Male - administration & dosage
- Middle Aged - administration & dosage
- Patient Admission - statistics & numerical data
- Prediabetic State - mortality, virology
- Prospective Studies - administration & dosage
- Retrospective Studies - administration & dosage
- Risk Assessment - administration & dosage
- Risk Factors - administration & dosage
- SARS-CoV-2 - administration & dosage
- Find related publications in this database (Keywords)
- coronavirus infection
- diabetes
- prediabetic state