Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Moritz, J; Bauernhofer, T; Mannweiler, S; Langsenlehner, T; Pummer, K; Dandachi, N; Pichler, M.
Evaluation of Blood-based Biomarkers for Prediction of Response in Carboplatin-treated Metastatic Castration-resistant Prostate Cancer Patients.
In Vivo. 2020; 34(6): 3631-3638.
Doi: 10.21873/invivo.12209
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Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Dandachi Nadia
- Moritz Jennifer Monika
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Bauernhofer Thomas
- Langsenlehner Tanja
- Mannweiler Sebastian
- Pummer Karl
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- Abstract:
- Carboplatin-containing treatment regimens demonstrate moderate efficacy in metastatic castration-resistant prostate cancer (mCRPC). In this study, we retrospectively analyzed the efficacy of carboplatin in relation to blood-based parameters. A retrospective chart review was performed for 20 patients with mCRPC who received carboplatin in a single center. Median overall survival was 3.8 months (95%CI=1.5-7.1), median progression-free survival was 1.7 months. We observed two partial remissions (PR, 10%), four stable diseases (SD, 20%) and 14 disease progressions (PD, 70%), resulting in a clinical benefit rate of 30%. A doubling of NSE (neurone specific enolase) values was associated with a 19% absolute higher response rate (95%CI=14-23, p=0.027). All other laboratory parameters failed as predictive markers of response to carboplatin. In univariate Cox regression analysis, only NSE was significantly associated with impaired PFS (HR=0.7, 95%CI=0.56-0.96, p=0.030). Carboplatin showed moderate efficacy against mCRPC in this unselected population of patients and NSE levels may help to predict the success of this treatment. Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
- Find related publications in this database (Keywords)
- Metastatic castration-resistant prostate cancer
- carboplatin
- neurone specific enolase