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Moritz, J; Bauernhofer, T; Mannweiler, S; Langsenlehner, T; Pummer, K; Dandachi, N; Pichler, M.
Evaluation of Blood-based Biomarkers for Prediction of Response in Carboplatin-treated Metastatic Castration-resistant Prostate Cancer Patients.
In Vivo. 2020; 34(6): 3631-3638. Doi: 10.21873/invivo.12209 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Dandachi Nadia
Moritz Jennifer Monika
Pichler Martin
Co-Autor*innen der Med Uni Graz
Bauernhofer Thomas
Langsenlehner Tanja
Mannweiler Sebastian
Pummer Karl

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Carboplatin-containing treatment regimens demonstrate moderate efficacy in metastatic castration-resistant prostate cancer (mCRPC). In this study, we retrospectively analyzed the efficacy of carboplatin in relation to blood-based parameters. A retrospective chart review was performed for 20 patients with mCRPC who received carboplatin in a single center. Median overall survival was 3.8 months (95%CI=1.5-7.1), median progression-free survival was 1.7 months. We observed two partial remissions (PR, 10%), four stable diseases (SD, 20%) and 14 disease progressions (PD, 70%), resulting in a clinical benefit rate of 30%. A doubling of NSE (neurone specific enolase) values was associated with a 19% absolute higher response rate (95%CI=14-23, p=0.027). All other laboratory parameters failed as predictive markers of response to carboplatin. In univariate Cox regression analysis, only NSE was significantly associated with impaired PFS (HR=0.7, 95%CI=0.56-0.96, p=0.030). Carboplatin showed moderate efficacy against mCRPC in this unselected population of patients and NSE levels may help to predict the success of this treatment. Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Find related publications in this database (Keywords)
Metastatic castration-resistant prostate cancer
neurone specific enolase
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