Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stelzl, A; Aziz, F; Riedl, JM; Posch, F; Smolle, MA; Stojakovic, T; Terbuch, A; Pichler, M; Bergovec, M; Leithner, A; Liegl-Atzwanger, B; Stotz, M; Gerger, A; Sourij, H; Szkandera, J.
Diabetes mellitus is independently associated with adverse clinical outcome in soft tissue sarcoma patients.
Sci Rep. 2020; 10(1): 12438-12438.
Doi: 10.1038/s41598-020-69237-y
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- Führende Autor*innen der Med Uni Graz
- Riedl Jakob
- Stelzl Adrian
- Co-Autor*innen der Med Uni Graz
- Aziz Faisal
- Bergovec Marko
- Gerger Armin
- Leithner Andreas
- Liegl-Atzwanger Bernadette
- Pichler Martin
- Posch Florian
- Smolle Maria Anna
- Sourij Harald
- Stojakovic Tatjana
- Stotz Michael
- Szkandera Joanna
- Terbuch Angelika
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- Abstract:
- Diabetes mellitus (DM) and hyperglycemia are known predictors of adverse outcome in different tumor entities. The present study investigated the effect of DM and pre-surgery blood glucose levels on cancer specific survival (CSS), overall survival (OS), and disease-free survival (DFS) in non-metastatic soft tissue sarcoma (STS) patients. A total of 475 STS patients who underwent curative resection were included in this retrospective study. CSS, DFS, and OS were assessed using Kaplan-Meier curves. The association between pre-existing DM as well as mean pre-surgery blood glucose levels and all 3 survival endpoints was analyzed using Cox-hazard proportional (for OS and DFS) and competing risk regression models (for CSS). In unadjusted analysis, DM was significantly associated with adverse CSS (sub-hazard ratio [SHR]: 2.14, 95% confidence interval [CI] 1.18-3.90, p = 0.013) and OS (hazard ratio [HR]: 2.05, 95% CI 1.28-3.28) and remained significant after adjusting for established prognostic factors (CSS: adjusted SHR 2.33, 95% CI 1.21-4.49, p = 0.012; OS: adjusted HR 1.96, 95% CI 1.17-3.28, p = 0.010), respectively. There was no significant association of DM with DFS (p = 0.149). The mean pre-surgery glucose levels were not significantly associated with inferior outcome (CSS: p = 0.510, OS: p = 0.382 and DFS: p = 0.786). This study shows, that DM represents a negative prognostic factor for clinical outcome in STS patients after curative resection.