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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Uranues, S; Bretthauer, G; Tomasch, G; Rafolt, D; Nagele-Moser, D; Berghold, A; Kleinert, R; Justich, I; Waldert, J; Koch, H.
A New Synthetic Conduit for the Treatment of Peripheral Nerve Injuries
WORLD J SURG. 2020;
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Berghold Andrea
Justich Ivo
Kleinert Reinhold
Koch Horst
Nagele-Moser Doris
Tomasch Gordana
Uranues M.A.Selman
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Abstract:
Background Peripheral nerve defects (PND) often cause lifelong physical disability, and the available treatment options are often not satisfactory. PND are usually bridged with an autologous nerve transplant or a nerve guidance conduit (NGC), when coaptation as preferred technique is not possible. The aim of this experimental study was to determine the effectiveness of a novel NGC for regeneration in the treatment of PND. Materials and methods A conduit made of gelatin with an innovative interior structure was tested for the repair of a 6-mm gap versus direct microsurgical suture repair without gap. Results We found that bridging the defect with this conduit was as effective as direct microsurgical coaptation without a defect. Conclusions This nerve conduit, effective in bridging neural defects, appears as an alternative to autologous nerve grafts, avoiding the problems related to nerve graft harvesting, host-donor differences in diameter, mismatches in number and pattern of fascicles, cross-sectional shape and area, and morbidity of the donor area.

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