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Birkl, C; Birkl-Toeglhofer, AM; Kames, C; Goessler, W; Haybaeck, J; Fazekas, F; Ropele, S; Rauscher, A.
The influence of iron oxidation state on quantitative MRI parameters in post mortem human brain.
Neuroimage. 2020; 220:117080 Doi: 10.1016/j.neuroimage.2020.117080 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Birkl Christoph
Co-Autor*innen der Med Uni Graz
Birkl-Töglhofer Anna Maria
Fazekas Franz
Haybäck Johannes
Ropele Stefan

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A variety of Magnetic Resonance Imaging (MRI) techniques are known to be sensitive to brain iron content. In principle, iron sensitive MRI techniques are based on local magnetic field variations caused by iron particles in tissue. The purpose of this study was to investigate the sensitivity of MR relaxation and magnetization transfer parameters to changes in iron oxidation state compared to changes in iron concentration. Therefore, quantitative MRI parameters including R1, R2, R2∗, quantitative susceptibility maps (QSM) and magnetization transfer ratio (MTR) of post mortem human brain tissue were acquired prior and after chemical iron reduction to change the iron oxidation state and chemical iron extraction to decrease the total iron concentration. All assessed parameters were shown to be sensitive to changes in iron concentration whereas only R2, R2∗ and QSM were also sensitive to changes in iron oxidation state. Mass spectrometry confirmed that iron accumulated in the extraction solution but not in the reduction solution. R2∗ and QSM are often used as markers for iron content. Changes in these parameters do not necessarily reflect variations in iron content but may also be a result of changes in the iron's oxygenation state from ferric towards more ferrous iron or vice versa.
Find related publications in this database (using NLM MeSH Indexing)
Aged - administration & dosage
Aged, 80 and over - administration & dosage
Brain - diagnostic imaging, metabolism
Brain Mapping - administration & dosage
Female - administration & dosage
Humans - administration & dosage
Image Interpretation, Computer-Assisted - administration & dosage
Iron - metabolism
Magnetic Resonance Imaging - administration & dosage
Male - administration & dosage
Middle Aged - administration & dosage

Find related publications in this database (Keywords)
Brain iron
Iron oxidation state
Ferric iron
Ferrous iron
Quantitative MRI
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