Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Birkl, C; Birkl-Toeglhofer, AM; Kames, C; Goessler, W; Haybaeck, J; Fazekas, F; Ropele, S; Rauscher, A.
The influence of iron oxidation state on quantitative MRI parameters in post mortem human brain.
Neuroimage. 2020; 220:117080
Doi: 10.1016/j.neuroimage.2020.117080
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- Führende Autor*innen der Med Uni Graz
- Birkl Christoph
- Co-Autor*innen der Med Uni Graz
- Birkl-Töglhofer Anna Maria
- Fazekas Franz
- Haybäck Johannes
- Ropele Stefan
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- Abstract:
- A variety of Magnetic Resonance Imaging (MRI) techniques are known to be sensitive to brain iron content. In principle, iron sensitive MRI techniques are based on local magnetic field variations caused by iron particles in tissue. The purpose of this study was to investigate the sensitivity of MR relaxation and magnetization transfer parameters to changes in iron oxidation state compared to changes in iron concentration. Therefore, quantitative MRI parameters including R1, R2, R2∗, quantitative susceptibility maps (QSM) and magnetization transfer ratio (MTR) of post mortem human brain tissue were acquired prior and after chemical iron reduction to change the iron oxidation state and chemical iron extraction to decrease the total iron concentration. All assessed parameters were shown to be sensitive to changes in iron concentration whereas only R2, R2∗ and QSM were also sensitive to changes in iron oxidation state. Mass spectrometry confirmed that iron accumulated in the extraction solution but not in the reduction solution. R2∗ and QSM are often used as markers for iron content. Changes in these parameters do not necessarily reflect variations in iron content but may also be a result of changes in the iron's oxygenation state from ferric towards more ferrous iron or vice versa.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Brain - diagnostic imaging, metabolism
- Brain Mapping - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Image Interpretation, Computer-Assisted - administration & dosage
- Iron - metabolism
- Magnetic Resonance Imaging - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Find related publications in this database (Keywords)
- Brain iron
- Iron oxidation state
- Ferric iron
- Ferrous iron
- Quantitative MRI