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SHR Neuro Krebs Kardio Lipid

Guenter, S; Gorkiewicz, G; Halwachs, B; Kashofer, K; Thueringer, A; Wurm, P; Zollner-Schwetz, I; Valentin, T; Prattes, J; Wunsch, S; Ullrich, E; Zurl, C; Hoenigl, M; Krause, R.
Impact of ITS-Based Sequencing on Antifungal Treatment of Patients with Suspected Invasive Fungal Infections.
J Fungi (Basel). 2020; 6(2): [OPEN ACCESS]
PubMed PUBMED Central FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Gorkiewicz Gregor
Halwachs-Wenzl Bettina
Hönigl Martin
Kashofer Karl
König Elisabeth
Krause Robert
Prattes Jürgen
Valentin Thomas
Wunsch Stefanie
Wurm Philipp
Zollner-Schwetz Ines
Zurl Christoph Johann
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Abstract:
Molecular techniques including the sequencing of fungal-specific DNA targets are increasingly used in the diagnosis of suspected invasive fungal infections. In contrast to established biomarkers like galactomannan or 1-3-β-d-glucan, the clinical impact of these methods remains unknown. We retrospectively investigated the impact of ITS1-sequencing on antifungal treatment strategies in 71 patients (81 samples) with suspected invasive fungal infections. ITS-sequencing either confirmed already ongoing antifungal therapy (19/71 patients, 27%), led to a change in antifungal therapy (11/71, 15%) or supported the decision to withhold antifungal treatment (34/71, 48%) (in seven of 71 patients, ITS-sequencing results were obtained postmortem). ITS-sequencing results led to a change in antifungal therapy in a relevant proportion of patients, while it confirmed therapeutic strategies in the majority. Therefore, ITS-sequencing was a useful adjunct to other fungal diagnostic measures in our cohort.

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