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Hochmeister, S; Gattringer, T; Asslaber, M; Stangl, V; Haindl, MT; Enzinger, C; Höftberger, R.
A Fulminant Case of Demyelinating Encephalitis With Extensive Cortical Involvement Associated With Anti-MOG Antibodies.
Front Neurol. 2020; 11: 31-31. Doi: 10.3389/fneur.2020.00031 (- Case Report) [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Hochmeister Sonja
Co-Autor*innen der Med Uni Graz
Asslaber Martin
Enzinger Christian
Gattringer Thomas
Haindl Michaela Tanja
Stangl Verena Maria

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Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies (MOG-Abs) are commonly associated with clinical presentations as acute disseminated encephalomyelitis (ADEM) in both adults and children and anti-aquaporin 4 antibody-seronegative neuromyelitis optica spectrum disorder (NMOSD) and related syndromes such as optic neuritis, myelitis, and brainstem encephalitis. Most often, the presence of MOG-Abs is associated with a more benign clinical course and a good response to steroids. Here, we present a case report of a previously healthy 52-year-old female patient with fulminant demyelinating encephalitis, leading to death within a week after the first presenting symptoms from a massive brain edema irresponsive to high-dose intravenous steroids as well as osmotic therapy. The final diagnosis was only made postmortem after serum anti-MOG-Abs results were available. Histopathological analysis of the brain revealed extensive, predominantly cortical demyelinating lesions in the frontal, temporal, and parietal lobes with intracortical, leukocortical, and subpial plaques, associated with pronounced perivenous deposition of activated complement complex as well as features of acute MS characterized by destructive lesions. Copyright © 2020 Hochmeister, Gattringer, Asslaber, Stangl, Haindl, Enzinger and Höftberger.

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