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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Sastre-Garriga, J; Pareto, D; Battaglini, M; Rocca, MA; Ciccarelli, O; Enzinger, C; Wuerfel, J; Sormani, MP; Barkhof, F; Yousry, TA; De Stefano, N; Tintoré, M; Filippi, M; Gasperini, C; Kappos, L; Río, J; Frederiksen, J; Palace, J; Vrenken, H; Montalban, X; Rovira, À; MAGNIMS study group.
MAGNIMS consensus recommendations on the use of brain and spinal cord atrophy measures in clinical practice.
Nat Rev Neurol. 2020; 16(3):171-182 Doi: 10.1038/s41582-020-0314-x [OPEN ACCESS]
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Enzinger Christian

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Early evaluation of treatment response and prediction of disease evolution are key issues in the management of people with multiple sclerosis (MS). In the past 20 years, MRI has become the most useful paraclinical tool in both situations and is used clinically to assess the inflammatory component of the disease, particularly the presence and evolution of focal lesions - the pathological hallmark of MS. However, diffuse neurodegenerative processes that are at least partly independent of inflammatory mechanisms can develop early in people with MS and are closely related to disability. The effects of these neurodegenerative processes at a macroscopic level can be quantified by estimation of brain and spinal cord atrophy with MRI. MRI measurements of atrophy in MS have also been proposed as a complementary approach to lesion assessment to facilitate the prediction of clinical outcomes and to assess treatment responses. In this Consensus statement, the Magnetic Resonance Imaging in MS (MAGNIMS) study group critically review the application of brain and spinal cord atrophy in clinical practice in the management of MS, considering the role of atrophy measures in prognosis and treatment monitoring and the barriers to clinical use of these measures. On the basis of this review, the group makes consensus statements and recommendations for future research.
Find related publications in this database (using NLM MeSH Indexing)
Atrophy - diagnostic imaging
Atrophy - pathology
Brain - diagnostic imaging
Brain - pathology
Consensus -
Humans -
Magnetic Resonance Imaging - methods
Magnetic Resonance Imaging - standards
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - pathology
Practice Guidelines as Topic - standards
Prognosis -
Randomized Controlled Trials as Topic - standards
Severity of Illness Index -
Spinal Cord - diagnostic imaging
Spinal Cord - pathology

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