Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hsieh, PL; Liao, YW; Pichler, M; Yu, CC.
MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells.
Cancers (Basel). 2020; 12(2): 340
Doi: 10.3390/cancers12020340
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- Co-Autor*innen der Med Uni Graz
- Pichler Martin
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- Abstract:
- Oral cancer belongs to head and neck squamous cell carcinoma and has been recognized as one of the most prevalent malignancies worldwide. Recent studies have suggested that cancer stem cells (CSCs) may participate in tumor initiation, metastasis and even recurrence, so the regulation of CSCs has drawn significant attention over the past decade. Among various molecules that are associated with CSCs, non-coding RNAs (ncRNAs) have been indicated as key players in the acquisition and maintenance of cancer stemness. In addition, accumulating studies have shown that the aberrant expression of these ncRNAs may serve as surrogate diagnostic markers or even therapeutic targets for cancer treatment. The current study reviews the previous work by us and others to summarize how these ncRNAs affect oral cancer stemness and their potential theranostic applications. A better understanding of the implication of these ncRNAs in oral tumorigenesis will facilitate the translation of basic ncRNA research into clinical application in the future.
- Find related publications in this database (Keywords)
- head and neck squamous cell carcinoma
- oral cancer
- cancer stem cells
- non-coding RNAs