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Kober, SE; Pinter, D; Enzinger, C; Damulina, A; Duckstein, H; Fuchs, S; Neuper, C; Wood, G.
Self-regulation of brain activity and its effect on cognitive function in patients with multiple sclerosis - First insights from an interventional study using neurofeedback.
Clin Neurophysiol. 2019; 130(11):2124-2131 Doi: 10.1016/j.clinph.2019.08.025
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Co-Autor*innen der Med Uni Graz
Damulina Anna
Enzinger Christian
Fuchs Siegrid
Pinter Daniela Theresia

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To investigate the effects of EEG-based neurofeedback training, in which one can learn to self-regulate one's own brain activity, on cognitive function in patients with multiple sclerosis (pwMS). Fourteen pwMS performed ten neurofeedback training sessions within 3-4 weeks at home using a tele-rehabilitation system. The aim of the neurofeedback training was to increase voluntarily the sensorimotor rhythm (SMR, 12-15 Hz) in the EEG over central brain areas by receiving visual real-time feedback thereof. Cognitive function was assessed before and after all neurofeedback training sessions using a comprehensive standardized neuropsychological test battery. Half of the pwMS (N = 7) showed cognitive improvements in long-term memory and executive functions after neurofeedback training. These patients successfully learned to self-regulate their own brain activity by means of neurofeedback training. The other half of pwMS (N = 7) did neither show any cognitive changes when comparing the pre- and post-assessment nor were they able to modulate their own brain activity in the desired direction during neurofeedback training. Data from this interventional study provide first preliminary evidence that successful self-regulation of one's own brain activity may be associated with cognitive improvements in pwMS. These promising results should stimulate further studies. Neurofeedback might be a promising and alternative tool for future cognitive rehabilitation. Copyright © 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Find related publications in this database (Keywords)
Brain-computer interface
Cognitive training
Multiple sclerosis
Sensorimotor rhythm
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