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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Smolle, E; Fink-Neuboeck, N; Lindenmann, J; Smolle-Juettner, F; Pichler, M.
The Biological and Clinical Relevance of Inhibitor of Growth (ING) Genes in Non-Small Cell Lung Cancer.
Cancers (Basel). 2019; 11(8): Doi: 10.3390/cancers11081118 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Taucher Elisabeth Marie
Co-Autor*innen der Med Uni Graz
Fink-Neuböck Nicole
Lindenmann Jörg
Pichler Martin
Smolle-Juettner Freyja-Maria

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Carcinogenic mutations allow cells to escape governing mechanisms that commonly inhibit uncontrolled cell proliferation and maintain tightly regulated homeostasis between cell death and survival. Members of the inhibition of growth (ING) family act as tumor suppressors, governing cell cycle, apoptosis and cellular senescence. The molecular mechanism of action of ING genes, as well as their anchor points in pathways commonly linked to malignant transformation of cells, have been studied with respect to a variety of cancer specimens. This review of the current literature focuses specifically on the action mode of ING family members in lung cancer. We have summarized data from in vitro and in vivo studies, highlighting the effects of varying levels of ING expression in cancer cells. Based on the increasing insight into the function of these proteins, the use of ING family members as clinically useful biomarkers for lung cancer detection and prognosis will probably become routine in everyday clinical practice.

Find related publications in this database (Keywords)
Inhibition of growth
lung cancer
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