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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Schmidinger, M; Pichler, R; Loidl, W; Bauernhofer, T; Kretz, M; Tinchon, C; Niedersüß-Beke, D; Pfleger, G; Wiesinger, CG; Vogl, U; Mitterberger, M; Stöger, H; Tulchiner, G; Kratochvill, F; Gerritsmann, H; Mraz, B; Marszalek, M.
Real-World Evidence Data on Metastatic Renal-Cell Carcinoma Treatment in Austria: The RELACS Study.
Clin Genitourin Cancer. 2019; 17(5):e957-e967-e957-e967 Doi: 10.1016/j.clgc.2019.05.017 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz
Bauernhofer Thomas
Stöger Herbert

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Treatment decisions in routine clinical practice are based on reports of clinical trials, which represent highly selected populations. Limited studies reported real-world evidences representing routine clinical practices in patients with renal-cell carcinoma (RCC) in Europe. The aim of this retrospective, noninterventional chart review was to collect data on the treatment landscape for patients with advanced/metastatic RCC in routine clinical practice in a broader patient population in Austria. Patients with advanced/metastatic RCC receiving systemic treatment between June 2010 and June 2016 across 12 centers in Austria were included. Parameters were entered into an electronic case report form from the participating sites via the application Hermesoft electronic data capture system. Progression-free survival (PFS) and overall survival (OS) were the 2 primary end points. The median PFS and OS were 12 months and 44 months, respectively (first-line PFS was 14 months for pazopanib and 13 months for sunitinib; first-line OS was 44 months for pazopanib and 48 months for sunitinib). Factors influencing the OS were sex, with female patients at a significantly higher risk than male patients (hazard ratio = 1.719), Eastern Cooperative Oncology Group performance status > 0 increased the risk twice (hazard ratio = 2.048), and number of metastases > 3 before the first line doubled the risk compared to metastases (hazard ratio = 2.064). OS in this retrospective chart review was considerably longer than the previous reports in real-world patients, underlining the benefit of current RCC treatment options in routine clinical practice. Copyright © 2019. Published by Elsevier Inc.

Find related publications in this database (Keywords)
Overall survival
Progression-free survival
Real-world outcomes
Treatment patterns
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