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Manninger, M; Perl, S; Brussee, H; G Toth, G.
Sniff of coke breaks the heart: cocaine-induced coronary vasospasm aggravated by therapeutic hypothermia and vasopressors after aborted sudden cardiac death: a case report.
Eur Heart J Case Rep. 2018; 2(2):yty041-yty041 Doi: 10.1093/ehjcr/yty041 (- Case Report) [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Manninger-Wünscher Martin
Toth-Gayor Gabor
Co-Autor*innen der Med Uni Graz
Brussee Helmut
Perl Sabine

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Coronary vasospasm and sudden cardiac death are a frequently reported complication of cocaine abuse. We present a case with uniquely severe clinical and angiographic presentation. A 39-year-old patient was presented to the cath lab after out-of-hospital cardiac arrest. Coronary angiography revealed focal coronary vasospasm in the proximal LCx, well responsive for intracoronary nitrates. Accordingly, no coronary intervention was performed and the patient was transferred to the cardiac intensive care unit. There, after systematically cooling sudden haemodynamic deterioration and massive ST-elevation was observed. Repeated coronary angiography revealed subocclusive LAD and LCx vasospasm, which again recovered after intracoronary injection of nitric oxide. Coronary-spastic effect of cocaine and its potentially dreadful clinical consequences are well-described phenomena. As novelty this case emphasizes that standard of care, including systematic hypothermia and vasopressor administration after out-of-hospital cardiac arrest can potentiate cocaine-induced coronary spasm with dramatic outcomes.

Find related publications in this database (Keywords)
Sudden cardiac death
Coronary vasospasm
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