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Vehabovic-Delic, A; Balic, M; Rossmann, C; Bauernhofer, T; Deutschmann, HA; Schoellnast, H.
Volume Computed Tomography Perfusion Imaging: Evaluation of the Significance in Oncologic Follow-up of Metastasizing Renal Cell Carcinoma in the Early Period of Targeted Therapy - Preliminary Results.
J Comput Assist Tomogr. 2019; 43(3):493-498 Doi: 10.1097/RCT.0000000000000848
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Führende Autor*innen der Med Uni Graz
Balic Marija
Schoellnast Helmut
Co-Autor*innen der Med Uni Graz
Bauernhofer Thomas
Deutschmann Hannes
Roßmann Christopher Herbert

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The aim of this study was to assess the significance of volume computed tomography perfusion imaging of metastasizing renal cell carcinoma (mRCC) in the early period after the initiation of targeted therapy. Blood flow (BF), blood volume, and clearance (CL) were calculated in 10 patients with histologically verified mRCC before and 1 month after initiation of targeted therapy using compartmental analysis algorithms. In addition, the longest diameter of tumor was measured for both time points and compared. Correlation test was performed between perfusion parameters and size changes with time to progression (TTP). Blood flow and CL were significantly lower after therapy initiation, whereas blood volume and the long diameter remained unchanged. Median values before and after 4 weeks of therapy were 144.2 versus 99.4 mL/min/100 mL for BF (P = 0.009) and 115.5 versus 46.8 mL/min/100 mL for CL (P = 0.007). Changes in BF and CL showed very strong negative correlation with TTP (r = -0.838, P = 0.009 and r = -0.826, P = 0.011, respectively). Our preliminary study results indicate that volume computed tomography perfusion may assess targeted therapy response of mRCC earlier than the currently used Response Evaluation Criteria in Solid Tumors. In addition, changes in BF and CL may be a promising parameter for prediction of TTP.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Algorithms -
Antineoplastic Agents - therapeutic use
Carcinoma, Renal Cell - blood supply
Carcinoma, Renal Cell - drug therapy
Cone-Beam Computed Tomography - methods
Female -
Humans -
Kidney Neoplasms - blood supply
Kidney Neoplasms - diagnostic imaging
Kidney Neoplasms - drug therapy
Male -
Middle Aged -
Molecular Targeted Therapy - methods
Neoplasm Metastasis - diagnostic imaging
Perfusion Imaging - methods
Prospective Studies -
Treatment Outcome -

Find related publications in this database (Keywords)
volume computed tomography perfusion
tumor angiogenesis
response to treatment
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