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Smolle, MA; Kashofer, K; Riedl, JM; Stotz, M; Gerger, A.
Genetic Analysis Using a Gene Panel in 87 Caucasian Patients With Colorectal Cancer: Own Results and Review of Literature.
Anticancer Res. 2019; 39(2): 847-852. Doi: 10.21873/anticanres.13184
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Führende Autor*innen der Med Uni Graz
Smolle Maria Anna
Co-Autor*innen der Med Uni Graz
Gerger Armin
Kashofer Karl
Riedl Jakob
Stotz Michael

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Colorectal cancer (CRC) is the third most common cancer worldwide. The prognosis between left- and right-sided CRC differs, partly due to baseline differences as vascular supply. The purpose of the present study was to investigate whether there are genetic differences between left- and right-sided CRC. Eighty-seven patients with CRC (mean age: 61 years) were retrospectively included in the study. Blood samples were used for genetic analysis, by applying the sequencing research panel Ion AmpliSeq Colon and Lung Cancer Research Panel V2. Statistical analyses included Chi-square tests, Kaplan-Meier survival curves, and univariate/multivariate Cox-regression analyses. By testing the sequence of 22 genes included in the panel, a significant difference was detected between left- and right-sided CRC regarding the expression of BRAF and DDR2 genes, with mutations occurring more often in the right-sided CRC. In the multivariate setting, left-sided CRC only turned out as a significant positive prognostic parameter regarding progression-free survival, irrespective of the type of chemotherapy or BRAF and NRAS mutations. Tumour location was the only parameter proven to be an independent prognostic factor for CRC in the present study. Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Find related publications in this database (Keywords)
Colorectal cancer
genetic analysis
prognostic markers
right-sided CRC
left-sided CRC
BRAF gene
DDR2 gene
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