Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Homayoon, N; Pirpamer, L; Franthal, S; Katschnig-Winter, P; Kögl, M; Seiler, S; Wenzel, K; Hofer, E; Deutschmann, H; Fazekas, F; Langkammer, C; Ropele, S; Schmidt, R; Schwingenschuh, P.
Nigral iron deposition in common tremor disorders.
Mov Disord. 2019; 34(1):129-132
Doi: 10.1002/mds.27549
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- Führende Autor*innen der Med Uni Graz
- Homayoon Nina
- Schwingenschuh Petra
- Co-Autor*innen der Med Uni Graz
- Deutschmann Hannes
- Fazekas Franz
- Franthal Sebastian Othmar
- Hofer Edith
- Katschnig-Winter Petra
- Langkammer Christian
- Pirpamer Lukas
- Ropele Stefan
- Schmidt Reinhold
- Seiler Stephan
- Wenzel Karoline
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- Abstract:
- We investigated R2* relaxation rates as a marker of iron content in the substantia nigra in patients with common tremor disorders and explored their diagnostic properties. Mean nigral R2* rates were measured in 40 patients with tremor-dominant Parkinson's disease (PD), 15 with tremor in dystonia, 25 with essential tremor, and 25 healthy controls. Tremor-dominant PD patients had significantly higher nigral R2* values (34.1 ± 5.7) than those with tremor in dystonia (30.0 ± 3.9), essential tremor (30.6 ± 4.8), and controls (30.0 ± 2.8). An R2* threshold of 31.15 separated tremor-dominant PD from controls with a sensitivity and specificity of 67.5% and 72%. The sensitivity and specificity for discrimination between PD and non-PD tremor patients was 67.5% and 60%. Iron content in the substantia nigra is significantly higher in tremor-dominant PD than in tremor in dystonia, essential tremor, and controls. Because of the considerable overlap, nigral R2* cannot be suggested as a useful diagnostic tool. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Biomarkers - analysis
- Female -
- Humans -
- Iron - metabolism
- Magnetic Resonance Imaging - methods
- Male -
- Middle Aged -
- Parkinson Disease - diagnosis
- Parkinson Disease - metabolism
- Substantia Nigra - metabolism
- Substantia Nigra - physiopathology
- Tremor - metabolism
- Tremor - physiopathology
- Find related publications in this database (Keywords)
- brain iron accumulation
- essential tremor
- tremor-dominant Parkinson's disease
- tremor in dystonia
- R2 Star