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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Prüller, F; Bis, L; Milke, OL; Fruhwald, F; Pätzold, S; Altmanninger-Sock, S; Siller-Matula, J; von Lewinski, F; Ablasser, K; Sacherer, M; von Lewinski, D.
Cangrelor Induces More Potent Platelet Inhibition without Increasing Bleeding in Resuscitated Patients.
J Clin Med. 2018; 7(11): Doi: 10.3390/jcm7110442 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Prüller Florian
von Lewinski Dirk
Co-Autor*innen der Med Uni Graz
Ablasser Klemens
Fruhwald Friedrich
Pätzold Sascha
Sacherer Michael
von Lewinski Friederike

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Dual antiplatelet therapy is the standard of care for patients with myocardial infarction (MI), who have been resuscitated and treated with therapeutic hypothermia (TH). We compare the antiplatelet effect and bleeding risk of intravenous cangrelor to oral P2Y12-inhibitors in patients with MI receiving TH in a prospective comparison of two matched patient cohorts. Twenty-five patients within the CANGRELOR cohort were compared to 17 patients receiving oral P2Y12-inhibitors. CANGRELOR group (NCT03445546) and the ORAL P2Y12 Group (NCT02914795) were registered at Platelet function testing was performed using light-transmittance aggregometry and monitored for 4 days. P2Y12-inhibition was stronger in CANGRELOR compared to ORAL P2Y12 (adenosine diphosphate (ADP) (area under the curve (AUC)) 26.0 (5.9⁻71.6) vs. 160.9 (47.1⁻193.7)) at day 1. This difference decreased over the following days as more patients were switched from CANGRELOR to oral P2Y12-inhibitor treatment. There was no difference in the effect of aspirin between the two groups. We did not observe significant differences with respect to thrombolysis in myocardial infarction (TIMI) or Bleeding Academic Research Consortium (BARC) classified bleedings, number of blood transfusions or drop in haemoglobin B (Hb) or hematocrit (Hct) over time. Cangrelor treatment is not only feasible and effective in resuscitated patients, but also inhibited platelet function more effectively than orally administered P2Y12-inhibitors without an increased event rate for bleeding.

Find related publications in this database (Keywords)
platelet function
light transmission tomography
myocardial infarction
acute coronary syndrome
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