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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Abdellatif, M; Sedej, S; Carmona-Gutierrez, D; Madeo, F; Kroemer, G.
Autophagy in Cardiovascular Aging.
Circ Res. 2018; 123(7):803-824 Doi: 10.1161/CIRCRESAHA.118.312208 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Abdellatif Mahmoud
Sedej Simon

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Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging promotes the structural and functional declines of both the heart and the blood circulation system. In this review, we revise the contribution of known longevity pathways to cardiovascular health and delineate the possibilities to interfere with them. In particular, we evaluate autophagy, the intracellular catabolic recycling system associated with life- and health-span extension. We present genetic models, pharmacological interventions, and dietary strategies that block, reduce, or enhance autophagy upon age-related cardiovascular deterioration. Caloric restriction or caloric restriction mimetics like metformin, spermidine, and rapamycin (all of which trigger autophagy) are among the most promising cardioprotective interventions during aging. We conclude that autophagy is a fundamental process to ensure cardiac and vascular health during aging and outline its putative therapeutic importance.
Find related publications in this database (using NLM MeSH Indexing)
Age Factors -
Aging - metabolism
Aging - pathology
Animals -
Autophagy - drug effects
Caloric Restriction -
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - pathology
Cardiovascular Diseases - physiopathology
Cardiovascular Diseases - prevention & control
Cardiovascular System - drug effects
Cardiovascular System - metabolism
Cardiovascular System - pathology
Cardiovascular System - physiopathology
Health Status -
Humans -
Longevity -
Metformin - therapeutic use
Protective Factors -
Risk Factors -
Sirolimus - therapeutic use
Spermidine - therapeutic use

Find related publications in this database (Keywords)
caloric restriction
cardiovascular diseases
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