Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Asamer, E; Szkandera, J; Gibiser, P; Lembeck, AL; Stojakovic, T; Kornprat, P; Lackner, C; Winder, T; Schlick, K; Stöger, H; Gerger, A; Pichler, M; Stotz, M.
Elevated amylase in plasma represents an adverse prognostic marker in patients with metastatic pancreatic cancer : A retrospective analysis.
Wien Klin Wochenschr. 2018; 130(19-20):569-574
Doi: 10.1007/s00508-018-1383-3
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- Führende Autor*innen der Med Uni Graz
- Stotz Michael
- Co-Autor*innen der Med Uni Graz
- Gerger Armin
- Kornprat Peter
- Lackner Karoline
- Pichler Martin
- Schlick Konstantin
- Stöger Herbert
- Stojakovic Tatjana
- Szkandera Joanna
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- Abstract:
- BACKGROUND AND AIM: The aim of this study was to investigate the prognostic relevance of plasma amylase and lipase concerning survival of patients suffering from metastatic pancreatic cancer (PC). METHOD: This retrospective study included 351 patients with metastatic PC, who were treated in a single academic institution. Cancer-specific survival (CSS) was analyzed using the Kaplan-Meier method. To further evaluate the prognostic significance of lipase and amylase, univariate and multivariate values were calculated using Cox proportional models. RESULTS: In univariate analysis, an increased amylase level was associated with shorter CSS in PC patients (hazard ratio HR = 1.258; 95% confidence interval CI = 1.011-1.566; p = 0.039). In multivariate analysis, including gender, age, CA19-9 and administration of chemotherapy, increased amylase levels prevailed as an independent prognostic factor for CSS (HR = 1.373; 95%CI = 1.004-1.878; p = 0.047). CONCLUSIONS: Plasma amylase was found to be an independent prognostic factor in patients with metastatic PC. The results indicate that amylase might represent a novel and useful marker for better patient stratification in PC management.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - blood, enzymology
- Aged - administration & dosage
- Amylases - blood
- Biomarkers, Tumor - blood
- Female - administration & dosage
- Humans - administration & dosage
- Kaplan-Meier Estimate - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Pancreatic Neoplasms - blood, enzymology
- Prognosis - administration & dosage
- Proportional Hazards Models - administration & dosage
- Retrospective Studies - administration & dosage
- Find related publications in this database (Keywords)
- Lipase
- CA19-9
- Pancreas
- Pancreatitis
- Adenocarcinoma