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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Tripolt, NJ; Stekovic, S; Aberer, F; Url, J; Pferschy, PN; Schröder, S; Verheyen, N; Schmidt, A; Kolesnik, E; Narath, SH; Riedl, R; Obermayer-Pietsch, B; Pieber, TR; Madeo, F; Sourij, H.
Intermittent Fasting (Alternate Day Fasting) in Healthy, Non-obese Adults: Protocol for a Cohort Trial with an Embedded Randomized Controlled Pilot Trial.
Adv Ther. 2018; 35(8):1265-1283 Doi: 10.1007/s12325-018-0746-5 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Sourij Harald
Tripolt Norbert
Co-Autor*innen der Med Uni Graz
Aberer Felix
Kolesnik Ewald
Narath Sophie Helene
Obermayer-Pietsch Barbara
Pferschy Peter
Pieber Thomas
Riedl Regina
Schmidt Albrecht
Verheyen Nicolas Dominik

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Alternate day fasting (ADF) is a subtype of intermittent fasting and is defined as a continuous sequence of a fast day (100% energy restriction, zero calories) and a feed day (ad libitum food consumption), resulting in roughly 36-h fasting periods. Previous studies demonstrated weight reductions and improvements of cardiovascular risk factors with ADF in obese subjects. However, rigorous data on potential endocrine, metabolic and cardiovascular effects, besides weight loss, are lacking. Therefore we aim to investigate the short- and mid- to long-term clinical and molecular effects of ADF in healthy non-obese subjects. We will perform a prospective cohort study with an embedded randomized controlled trial (RCT) including 90 healthy subjects. Thirty of them will have performed ADF for at least 6 months (mid-term group). Sixty healthy subjects without a particular diet before enrolment will serve as the control group. These subjects will be 1:1 randomized to either continuing their current diet or performing ADF for 4 weeks. All subjects will undergo study procedures that will be repeated in RCT participants after 4 weeks. These procedures will include assessment of outcome parameters, dual-energy X-ray absorptiometry, measurement of endothelial function, an oral glucose tolerance test, 24-h blood pressure measurement, retinal vessel analysis, echocardiography and physical activity measurement by an accelerometer. Blood, sputum, buccal mucosa and faeces will be collected for laboratory analyses. Participants in the RCT will wear a continuous glucose monitor to verify adherence to the study intervention. The aim of this project is to investigate the effects of ADF on human physiology and molecular cellular processes. This investigation should gain in-depth mechanistic insights into the concept of ADF and form the basis for larger subsequent cohort recruitment and consecutive intervention studies. NCT02673515; registered 24 November 2015. Current protocol date/version: 7 February 2017/version 1.8.

Find related publications in this database (Keywords)
Alternate day fasting
Blood pressure
Cell death
Cell signalling
Cohort study
Endothelial function
Glucose metabolism
Healthy subjects
Insulin sensitivity
Intermittent fasting
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