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Gantenbein, N; Bernhart, E; Anders, I; Golob-Schwarzl, N; Krassnig, S; Wodlej, C; Brcic, L; Lindenmann, J; Fink-Neuboeck, N; Gollowitsch, F; Stacher-Priehse, E; Asslaber, M; Gogg-Kamerer, M; Rolff, J; Hoffmann, J; Silvestri, A; Regenbrecht, C; Reinhard, C; Pehserl, AM; Pichler, M; Sokolova, O; Naumann, M; Mitterer, V; Pertschy, B; Bergler, H; Popper, H; Sattler, W; Haybaeck, J.
Influence of eukaryotic translation initiation factor 6 on non-small cell lung cancer development and progression.
Eur J Cancer. 2018; 101(4):165-180 Doi: 10.1016/j.ejca.2018.07.001 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Gantenbein Nadine
Haybäck Johannes
Co-Autor*innen der Med Uni Graz
Anders Ines
Asslaber Martin
Bernhart Eva Maria
Brcic Luka
Fink-Neuböck Nicole
Gogg-Kamerer Margit
Gollowitsch Franz
Golob-Schwarzl Nicole
Kraßnig Stefanie
Lindenmann Jörg
Pehserl Anna-Maria
Pichler Martin
Popper Helmuth
Sattler Wolfgang
Skofler Christina
Stacher-Priehse Elvira

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Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Dysregulation of protein synthesis plays a major role in carcinogenesis, a process regulated at multiple levels, including translation of mRNA into proteins. Ribosome assembly requires correct association of ribosome subunits, which is ensured by eukaryotic translation initiation factors (eIFs). eIFs have become targets in cancer therapy studies, and promising data on eIF6 in various cancer entities have been reported. Therefore, we hypothesised that eIF6 represents a crossroad for pulmonary carcinogenesis. High levels of eIF6 are associated with shorter patient overall survival in adenocarcinoma (ADC), but not in squamous cell carcinoma (SQC) of the lung. We demonstrate significantly higher protein expression of eIF6 in ADC and SQC than in healthy lung tissue based on immunohistochemical data from tissue microarrays (TMAs) and on fresh frozen lung tissue. Depletion of eIF6 in ADC and SQC lung cancer cell lines inhibited cell proliferation and induced apoptosis. Knockdown of eIF6 led to pre-rRNA processing and ribosomal 60S maturation defects. Our data indicate that eIF6 is upregulated in NSCLC, suggesting an important contribution of eIF6 to the development and progression of NSCLC and a potential for new treatment strategies against NSCLC. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
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A549 Cells -
Adenocarcinoma - genetics
Adenocarcinoma - metabolism
Adenocarcinoma - pathology
Aged -
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Line, Tumor -
Cell Survival - genetics
Disease Progression -
Eukaryotic Initiation Factors - biosynthesis
Eukaryotic Initiation Factors - genetics
Female -
Humans -
Immunohistochemistry -
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Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Male -
RNA Interference -

Find related publications in this database (Keywords)
Non-small cell lung cancer
Squamous cell carcinoma
Eukaryotic translation initiation factor 6
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