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Jud, P; Hafner, F; Verheyen, N; Gary, T; Meinitzer, A; Brodmann, M; Seinost, G; Hackl, G.
Age-dependent effects of homocysteine and dimethylarginines on cardiovascular mortality in claudicant patients with lower extremity arterial disease.
Heart Vessels. 2018; 33(12):1453-1462 Doi: 10.1007/s00380-018-1210-9 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Jud Philipp
Co-Autor*innen der Med Uni Graz
Brodmann Marianne
Gary Thomas
Hackl Gerald
Hafner Franz
Meinitzer Andreas
Seinost Gerald
Verheyen Nicolas Dominik

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The association among serum homocysteine (HCY), symmetric dimethylarginine (SDMA), and asymmetric dimethylarginine (ADMA) is of interest in endothelial dysfunction, although the underlying pathology is not fully elucidated. We investigated the relationship of HCY with SDMA and ADMA regarding their long-time outcome and the age dependency of HCY, SDMA, and ADMA values in claudicant patients with lower extremity arterial disease. 120 patients were included in a prospective observational study (observation time 7.96 ± 1.3 years) with cardiovascular mortality as the main outcome parameter. Patients with intermittent claudication prior to their first endovascular procedure were included. HCY, SDMA, and ADMA were measured by high-performance liquid chromatography. Cutoff values for HCY (≤/>15 µmol/l), SDMA (≤/>0.75 µmol/l), and ADMA (≤/>0.8 µmol/l) differed significantly regarding cardiovascular mortality (p < 0.001, p < 0.001, p = 0.017, respectively). Age correlated significantly with HCY (r = 0.393; p < 0.001), SDMA (r = 0.363; p < 0.001), and ADMA (r = 0.210; p = 0.021). HCY and SDMA (r = 0.295; p = 0.001) as well as SDMA and ADMA (r = 0.380; p < 0.001) correlated with each other, while HCY and ADMA did not correlate (r = 0.139; p = 0.130). Patients older than 65 years had higher values of HCY (p < 0.001) and SDMA (p = 0.01), but not of ADMA (p = 0.133). In multivariable linear regression, age was the only significant independent risk factor for cardiovascular death (beta coefficient 0.413; 95% CI 0.007-0.028; p = 0.001). Age correlated significantly with HCY, SDMA, and ADMA. However, only age was an independent predictor for cardiovascular death. Older patients have higher values of HCY and SDMA than younger subjects suggesting age-adjusted cutoff values of HCY and SDMA due to strong age dependency.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aging - blood
Arginine - analogs & derivatives
Arginine - blood
Arginine - epidemiology
Cardiovascular Diseases - blood
Cardiovascular Diseases - complications
Cardiovascular Diseases - epidemiology
Female -
Homocysteine - blood
Humans -
Incidence -
Intermittent Claudication - blood
Intermittent Claudication - complications
Intermittent Claudication - mortality
Lower Extremity - blood supply
Male -
Prospective Studies -
Risk Factors -
Survival Rate - trends

Find related publications in this database (Keywords)
Peripheral arterial disease
Intermittent claudication
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