Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Manninger, M; Zweiker, D; van Hunnik, A; Alogna, A; Prassl, AJ; Schipke, J; Zeemering, S; Zirngast, B; Schönleitner, P; Schwarzl, M; Herbst, V; Thon-Gutschi, E; Huber, S; Rohrer, U; Ebner, J; Brussee, H; Pieske, BM; Heinzel, FR; Verheule, S; Antoons, G; Lueger, A; Mühlfeld, C; Plank, G; Schotten, U; Post, H; Scherr, D.
Arterial hypertension drives arrhythmia progression via specific structural remodeling in a porcine model of atrial fibrillation.
Heart Rhythm. 2018; 15(9):1328-1336
Doi: 10.1016/j.hrthm.2018.05.016
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Manninger-Wünscher Martin
- Co-Autor*innen der Med Uni Graz
- Alogna Alessio
- Antoons Gudrun
- Brussee Helmut
- Ebner Jakob
- Heinzel Frank
- Huber Stefan
- Lueger Andreas
- Pieske Burkert Mathias
- Plank Gernot
- Post Heiner
- Prassl Anton
- Rohrer Ursula
- Scherr Daniel
- Schönleitner Patrick
- Schwarzl Michael
- Trummer-Herbst Viktoria
- Zirngast Birgit
- Zweiker David
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- Abstract:
- Arterial hypertension (HT) contributes to progression of atrial fibrillation (AF) via unknown mechanisms. We aimed to characterize electrical and structural changes accounting for increased AF stability in a large animal model of rapid atrial pacing (RAP)-induced AF combined with desoxycorticosterone acetate (DOCA)-induced HT. Eighteen pigs were instrumented with right atrial endocardial pacemaker leads and custom-made pacemakers to induce AF by continuous RAP (600 beats/min). DOCA pellets were subcutaneously implanted in a subgroup of 9 animals (AF+HT group); the other 9 animals served as controls (AF group). Final experiments included electrophysiology studies, endocardial electroanatomic mapping, and high-density mapping with epicardial multielectrode arrays. In addition, 3-dimensional computational modeling was performed. DOCA implantation led to secondary HT (median [interquartile range] aortic pressure 109.9 [100-137] mm Hg in AF+HT vs 82.2 [79-96] mm Hg in AF; P < .05), increased AF stability (55.6% vs 12.5% of animals with AF episodes lasting >1 hour; P < .05), concentric left ventricular hypertrophy, atrial dilatation (119 ± 31 cm2 in AF+HT vs 78 ± 23 cm2 in AF; P < .05), and fibrosis. Collagen accumulation in the AF+HT group was mainly found in non-intermyocyte areas (1.62 ± 0.38 cm3 in AF+HT vs 0.96 ± 0.3 cm3 in AF; P < .05). Left and right atrial effective refractory periods, action potential durations, endo- and epicardial conduction velocities, and measures of AF complexity were comparable between the 2 groups. A 3-dimensional computational model confirmed an increase in AF stability observed in the in vivo experiments associated with increased atrial size. In this model of secondary HT, higher AF stability after 2 weeks of RAP is mainly driven by atrial dilatation. Copyright © 2018 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Atrial Fibrillation - etiology
- Atrial Fibrillation - physiopathology
- Atrial Fibrillation - therapy
- Atrial Remodeling -
- Blood Pressure - physiology
- Computer Simulation -
- Disease Models, Animal -
- Electrocardiography -
- Heart Atria - diagnostic imaging
- Heart Atria - physiopathology
- Heart Rate - physiology
- Hypertension - complications
- Hypertension - physiopathology
- Pacemaker, Artificial -
- Swine -
- Find related publications in this database (Keywords)
- Arterial hypertension
- Atrial dilatation
- Atrial fibrillation
- Atrial fibrosis
- Electrical remodeling
- Structural remodeling