Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schwetz, V; Scharnagl, H; Trummer, C; Stojakovic, T; Pandis, M; Grübler, MR; Verheyen, N; Gaksch, M; Zittermann, A; Aberer, F; Lerchbaum, E; Obermayer-Pietsch, B; Pieber, TR; März, W; Tomaschitz, A; Pilz, S.
Vitamin D supplementation and lipoprotein metabolism: A randomized controlled trial.
J Clin Lipidol. 2018; 12(3):588-596.e4
Doi: 10.1016/j.jacl.2018.03.079
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Scharnagl Hubert
- Theiler-Schwetz Verena
- Co-Autor*innen der Med Uni Graz
- Aberer Felix
- Grübler Martin
- Keppel Martin
- Lerchbaum Elisabeth
- März Winfried
- Obermayer-Pietsch Barbara
- Pandis Marlene
- Pieber Thomas
- Pilz Stefan
- Stojakovic Tatjana
- Tomaschitz Andreas
- Trummer Christian
- Verheyen Nicolas Dominik
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- Abstract:
- BACKGROUND: Vitamin D deficiency is associated with an unfavorable lipid profile, but whether and how vitamin D supplementation affects lipid metabolism is unclear. OBJECTIVE: To examine the effects of vitamin D supplementation on lipid and lipoprotein parameters. METHODS: This is a post hoc analysis of the single-center, double-blind, randomized, placebo-controlled Styrian Vitamin D Hypertension Trial (2011-2014). Two hundred individuals with arterial hypertension and 25-hydroxyvitamin D concentrations of <75 nmol/L were randomized to 2800 IU of vitamin D daily or placebo for 8 weeks. RESULTS: One hundred sixty-three participants (62.2 [53.1-68.4] years of age; 46% women) had available lipid data and were included in this analysis. Vitamin D supplementation significantly increased total cholesterol, triglycerides, very-low-density lipoprotein (VLDL) triglycerides, low-density lipoprotein (LDL) triglycerides, high-density lipoprotein (HDL) triglycerides, apolipoprotein B (ApoB), LDL-ApoB, ApoCII, ApoCIII, phospholipids, and ApoE (P < .05 for all). Except for ApoCII and ApoCIII and HDL-triglycerides, all other treatment effects remained statistically significant after adjustment for multiple testing with the Benjamini and Hochberg false discovery rate method. There was a nonsignificant increase in LDL cholesterol. Furthermore, no significant effects were seen on free fatty acids, lipoprotein (a), ApoAI, ApoAII, VLDL cholesterol, VLDL-ApoB, HDL cholesterol, LDL diameter, and VLDL diameter. CONCLUSIONS: The effects of vitamin D on lipid metabolism are potentially unfavorable. They require further investigation in view of the wide use of vitamin D testing and treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Dietary Supplements - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Lipoproteins - metabolism
- Male - administration & dosage
- Middle Aged - administration & dosage
- Vitamin D - pharmacology
- Find related publications in this database (Keywords)
- Vitamin D supplementation
- Lipids
- Lipid composition
- Apolipoprotein
- Triglycerides
- Total cholesterol
- Low-density lipoproteins
- High-density lipoproteins