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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Schwetz, V; Scharnagl, H; Trummer, C; Stojakovic, T; Pandis, M; Grübler, MR; Verheyen, N; Gaksch, M; Zittermann, A; Aberer, F; Lerchbaum, E; Obermayer-Pietsch, B; Pieber, TR; März, W; Tomaschitz, A; Pilz, S.
Vitamin D supplementation and lipoprotein metabolism: A randomized controlled trial.
J Clin Lipidol. 2018; 12(3):588-596.e4 Doi: 10.1016/j.jacl.2018.03.079
Web of Science PubMed FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Scharnagl Hubert
Theiler-Schwetz Verena
Co-Autor*innen der Med Uni Graz
Aberer Felix
Grübler Martin
Keppel Martin
Lerchbaum Elisabeth
März Winfried
Obermayer-Pietsch Barbara
Pandis Marlene
Pieber Thomas
Pilz Stefan
Stojakovic Tatjana
Tomaschitz Andreas
Trummer Christian
Verheyen Nicolas Dominik

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BACKGROUND: Vitamin D deficiency is associated with an unfavorable lipid profile, but whether and how vitamin D supplementation affects lipid metabolism is unclear. OBJECTIVE: To examine the effects of vitamin D supplementation on lipid and lipoprotein parameters. METHODS: This is a post hoc analysis of the single-center, double-blind, randomized, placebo-controlled Styrian Vitamin D Hypertension Trial (2011-2014). Two hundred individuals with arterial hypertension and 25-hydroxyvitamin D concentrations of <75 nmol/L were randomized to 2800 IU of vitamin D daily or placebo for 8 weeks. RESULTS: One hundred sixty-three participants (62.2 [53.1-68.4] years of age; 46% women) had available lipid data and were included in this analysis. Vitamin D supplementation significantly increased total cholesterol, triglycerides, very-low-density lipoprotein (VLDL) triglycerides, low-density lipoprotein (LDL) triglycerides, high-density lipoprotein (HDL) triglycerides, apolipoprotein B (ApoB), LDL-ApoB, ApoCII, ApoCIII, phospholipids, and ApoE (P < .05 for all). Except for ApoCII and ApoCIII and HDL-triglycerides, all other treatment effects remained statistically significant after adjustment for multiple testing with the Benjamini and Hochberg false discovery rate method. There was a nonsignificant increase in LDL cholesterol. Furthermore, no significant effects were seen on free fatty acids, lipoprotein (a), ApoAI, ApoAII, VLDL cholesterol, VLDL-ApoB, HDL cholesterol, LDL diameter, and VLDL diameter. CONCLUSIONS: The effects of vitamin D on lipid metabolism are potentially unfavorable. They require further investigation in view of the wide use of vitamin D testing and treatment.
Find related publications in this database (using NLM MeSH Indexing)
Aged - administration & dosage
Dietary Supplements - administration & dosage
Female - administration & dosage
Humans - administration & dosage
Lipoproteins - metabolism
Male - administration & dosage
Middle Aged - administration & dosage
Vitamin D - pharmacology

Find related publications in this database (Keywords)
Vitamin D supplementation
Lipid composition
Total cholesterol
Low-density lipoproteins
High-density lipoproteins
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