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Muster, V; Wallner, M; Schmidt, A; Kapl, M; von Lewinski, F; Rainer, P; Reittner, P; Tillich, M; Brader, P; Szolar, DH; von Lewinski, D.
Heart rate-reducing therapy with add-on ivabradine and bisoprolol before coronary computed tomographic angiography in a fast-track ambulatory setting.
J Int Med Res. 2018; 46(6):2249-2257 Doi: 10.1177/0300060518761302 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Nemecz Viktoria
von Lewinski Dirk
Wallner Markus
Co-Autor*innen der Med Uni Graz
Brader Peter
Rainer Peter
Reittner Pia
Schmidt Albrecht
von Lewinski Friederike

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Objective This study was performed to determine whether add-on oral ivabradine in patients treated with beta blockers 1 hour before coronary computed tomographic angiography (CCTA) is effective in lowering the heart rate and thus improving CCTA quality. Methods In this single-center cohort study, the data of 294 patients referred for ambulant CCTA were retrospectively screened. Patients with an initial heart rate of ≥75 bpm (n = 112) were pretreated with either a combination of bisoprolol and ivabradine or with bisoprolol alone. Results During the scan, there was no difference in heart rate between the two groups Likewise, there was no significant difference in additionally administered intravenous bradycardic agents, the number of motion artifacts, or the radiation dose. Both drug regimens were tolerated well. Conclusion Additive oral ivabradine 1 hour before CCTA does not result in a further reduction of the heart rate. Consequently, neither movement artifacts nor radiation dose can be reduced. Therefore, pretreatment with ivabradine does not seem reasonably appropriate in an outpatient clinical setting with short patient contact.

Find related publications in this database (Keywords)
Coronary computed tomographic angiography
fast track
heart rate
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