Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Brcic, L; Stanzer, S; Krenbek, D; Gruber-Moesenbacher, U; Absenger, G; Quehenberger, F; Valipour, A; Lindenmann, J; Stoeger, H; Al Effah, M; Fediuk, M; Balic, M; Popper, HH.
Immune cell landscape in therapy-naïve squamous cell and adenocarcinomas of the lung.
Virchows Arch. 2018; 472(4):589-598
Doi: 10.1007/s00428-018-2326-0
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- Führende Autor*innen der Med Uni Graz
- Brcic Luka
- Co-Autor*innen der Med Uni Graz
- Absenger Gudrun
- Balic Marija
- Fediuk Melanie
- Lindenmann Jörg
- Popper Helmuth
- Quehenberger Franz
- Stanzer Stefanie
- Stöger Herbert
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- Abstract:
- Squamous cell and adenocarcinomas of the lung develop different mechanisms during carcinogenesis to evade attacks of the immune system. Besides the well-known check-point control programmed death 1 and its ligand, many more mechanisms, acting either tumoricidal or in favor of tumor progression, exist. Analysis of the immune cell profiles in resected tissues and bronchoalveolar lavage samples and correlation between them and with overall survival data was performed. In all tumor samples in this study, cells of the immune system expressed a tumor-cooperating phenotype. High numbers of regulatory T cells, or alternatively expression of Vista on lymphocytes was present. Tumoricidal dendritic cells were absent in tumor tissue, and barely present in bronchoalveolar lavage, whereas tumor-friendly monocytoid and plasmocytoid dendritic cells were seen in both. Alveolar macrophages were predominantly differentiated into tumor-cooperating M2 types, whereas tumoricidal M1 macrophages were absent or rare. The expression of PDL1 on tumor cells did not correlate with any other immune cells. Expression of PD1 on lymphocytes was frequently encountered. None of analyzed immune cells showed correlation with overall survival. Immune cells in bronchoalveolar lavage and tissue did not correlate. For the first time, a tissue-based analysis of different immune cells in squamous cell and adenocarcinomas of the lung is provided, trying to explain their potential role in tumor development and progression. Discordant numbers of cells with bronchoalveolar lavage are most probably due to the fact that bronchoalveolar lavage reflects the situation in the whole lung, where chronic obstructive lung disease and other conditions are present.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - immunology
- Carcinoma, Squamous Cell - immunology
- Female -
- Humans -
- Lung Neoplasms - immunology
- Lymphocytes, Tumor-Infiltrating - immunology
- Male -
- Find related publications in this database (Keywords)
- Non-small-cell lung cancer
- Immune system
- Bronchoalveolar lavage
- Immune cells
- Dendritic cells
- Myeloid-derived suppressor cells