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SHR Neuro Krebs Kardio Lipid

Gilg, MM; Gröchenig, HP; Schlemmer, A; Eherer, A; Högenauer, C; Langner, C.
Secondary tumors of the gastrointestinal tract: origin, histology, and endoscopic findings.
Gastrointest Endosc. 2018;
PubMed FullText FullText_MUG


Autor/innen der Med Uni Graz:
Eherer Andreas
Gilg Magdalena Maria
Högenauer Christoph
Langner Cord
Schlemmer Andrea

Dimensions Citations:

Plum Analytics:
The gastrointestinal tract (GIT) is rarely affected by secondary tumors. Patients often present at advanced stage, and prognosis is dismal. This study aimed to analyze clinical, endoscopic and pathological features of secondary tumors that had been diagnosed endoscopically. We conducted a retrospective database analysis of 217 patients with secondary tumors of the GIT. Endoscopic findings and histological diagnoses were systematically re-evaluated. Malignant melanoma (n= 33, 15%), breast (n= 32, 15%) and pancreatic cancer (n=27, 12%) were the most common corresponding primaries. About one-third of secondary tumors was detected in the stomach (n=76, 35%), followed by small intestine (n=54, 25%) and rectum (n=53, 24%). Median time between diagnosis of primary and secondary tumors was 19 months (mean, 31, range 0-251) and this was particularly long for renal cell carcinoma and breast cancer (median 38 and 45 months, respectively). Direct invasion from extragastrointestinal malignancies was more common (56%) than vascular cancer spread (44%) and depended on both site of tumor involvement and corresponding primary. Lesions presented with various endoscopic patterns. In patients for whom a definitive diagnosis of cancer was known before the examination (n=168), a secondary tumor was included in differential diagnosis in only 48% of lesions. It is of note that the remaining cases were diagnosed endoscopically as primary tumor and rarely also as non-neoplastic change. Secondary tumors may affect all parts of the GIT. Malignant melanoma and breast and pancreatic cancer represent the most common primaries. Biopsy diagnosis is crucial to avoid misclassification. Copyright © 2018 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

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