Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Shen, P; Pichler, M; Chen, M; Calin, GA; Ling, H.
To Wnt or Lose: The Missing Non-Coding Linc in Colorectal Cancer.
Int J Mol Sci. 2017; 18(9):
Doi: 10.3390/ijms18092003
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Pichler Martin
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- Abstract:
- Colorectal cancer (CRC) is the third most frequent cancer and one of the leading causes for cancer-related mortality. Aberrant activation of the Wnt signaling is an essential initiating factor in colon carcinogenesis, and a driving force of CRC progression. Recently, long non-coding RNAs (lncRNAs) have emerged as significant players in CRC pathogenesis through diversified mechanisms. Although both Wnt signaling and lncRNAs represent interesting research areas for CRC, an effort of directly connecting these two areas is lacking. To fill in the knowledge gap, we focus on the reported findings of lncRNAs that regulate Wnt signaling or essential Wnt signaling targets. These include several newly discovered lncRNAs originated from the amplified cancer-associated chromosome 8q24 region that surrounds the essential Wnt target MYC gene, lncRNAs reported to be involved in CRC stem cells, and several individual lncRNAs connected to Wnt signaling through other mechanisms. This review will provide essential information that assists in understanding the missing link of lncRNAs to the classical Wnt signaling in CRC.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomarkers, Tumor - genetics
- Colorectal Neoplasms - genetics
- Colorectal Neoplasms - pathology
- Gene Expression Regulation, Neoplastic -
- Genetic Predisposition to Disease - genetics
- Humans -
- Models, Genetic -
- RNA, Long Noncoding - genetics
- Wnt Signaling Pathway - genetics
- Find related publications in this database (Keywords)
- Wnt
- long non-coding RNA
- CCAT1
- CCAT2
- PVT1
- H19