Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dandachi, N; Tiran, V; Lindenmann, J; Brcic, L; Fink-Neuboeck, N; Kashofer, K; Absenger, G; Bezan, A; Cote, RJ; Datar, R; Balic, M.
Frequency and clinical impact of preoperative circulating tumor cells in resectable non-metastatic lung adenocarcinomas.
Lung Cancer. 2017; 113(46):152-157
Doi: 10.1016/j.lungcan.2017.10.003
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Dandachi Nadia
- Co-Autor*innen der Med Uni Graz
- Absenger Gudrun
- Balic Marija
- Brcic Luka
- Fink-Neuböck Nicole
- Kashofer Karl
- Lindenmann Jörg
- Terbuch Angelika
- Tiran Verena
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- Abstract:
- Despite successful surgery, 30-50% of patients with resectable non-small cell lung cancer develop tumor recurrence within 5 years of surgery. In this prospective study, we performed CTC enumerations in 40 patients with non-metastatic lung adenocarcinoma (NMLA) using a size-based microfilter. Additionally, cfDNA isolated from plasma was analyzed in 35 out of 40 patients. CTCs were identified in 15 out of 40 patients (37.5%) with a range of 1-44 cells, whereas mutated cfDNA was only detected in 3 out of 35 patients (8.6%). Disease-free survival (DFS) was significantly associated with CTC positivity (log-rank p=0.025), grading (log-rank p=0.019), tumor stage (log-rank p=0.025) and lymph node status (log-rank p=0.029). Multivariate analysis, including tumor stage and grading, showed that CTC positivity (p=0.006), grading (0.039) and tumor stage (p=0.022) were independently associated with DFS. Our study found that microfilter-based CTC enumeration in NMLA patients is an independent predictor of worse DFS. The used NGS-based cfDNA characterization had limited sensitivity to be clinically informative in our study cohort. CTC assessment before surgery can thus identify NMLA patients at high risk of disease recurrence. Copyright © 2017 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - blood
- Adenocarcinoma - genetics
- Adenocarcinoma - pathology
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers, Tumor - blood
- Biomarkers, Tumor - genetics
- Cell-Free Nucleic Acids - blood
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Lung Neoplasms - blood
- Lung Neoplasms - genetics
- Lung Neoplasms - pathology
- Male -
- Middle Aged -
- Neoplasm Grading -
- Neoplasm Staging -
- Neoplastic Cells, Circulating - metabolism
- Neoplastic Cells, Circulating - pathology
- Preoperative Period -
- Prognosis -
- Prospective Studies -
- Find related publications in this database (Keywords)
- Circulating tumor cells
- Non-metastatic
- Preoperative
- Lung cancer
- Recurrence