Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Krones, E; Pollheimer, MJ; Rosenkranz, AR; Fickert, P.
Cholemic nephropathy - Historical notes and novel perspectives.
Biochim Biophys Acta Mol Basis Dis. 2018; 1864(4 Pt B):1356-1366 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Fickert Peter
Krones Elisabeth
Pollheimer Marion
Rosenkranz Alexander
Altmetrics:

Dimensions Citations:

Plum Analytics:
Abstract:
Acute kidney injury is common in patients with liver disease and associated with significant morbidity and mortality. Besides bacterial infections, fluid loss, and use of nephrotoxic drugs AKI in liver disease may be triggered by tubular toxicity of cholephiles. Cholemic nephropathy, also known as bile cast nephropathy, supposedly represents a widely underestimated but important cause of renal dysfunction in cholestasic or advanced liver diseases with jaundice. Cholemic nephropathy describes impaired renal function along with characteristic histomorphological changes consisting of intratubular cast formation and tubular epithelial cell injury directed towards distal nephron segments. The underlying pathophysiologic mechanisms are not entirely understood and clear defined diagnostic criteria are still missing. This review aims to summarize (i) the present knowledge on clinical and morphological characteristics of cholemic nephropathy, (ii) available preclinical models, (iii) potential pathomechanisms especially the potential role of bile acids, and (iv) future diagnostic and therapeutic strategies for cholemic nephropathy. This article is part of a Special Issue entitled: Cholangiocytes in Health and Disease edited by Jesus Banales, Marco Marzioni, Nicholas LaRusso and Peter Jansen. Copyright © 2017 Elsevier B.V. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Acute Kidney Injury - diagnosis
Acute Kidney Injury - drug therapy
Acute Kidney Injury - etiology
Acute Kidney Injury - pathology
Animals -
Bile Acids and Salts - metabolism
Bile Acids and Salts - toxicity
Bile Ducts - cytology
Bile Ducts - drug effects
Bile Ducts - metabolism
Bile Ducts - pathology
Bilirubin - metabolism
Bilirubin - toxicity
Cholagogues and Choleretics - pharmacology
Cholagogues and Choleretics - therapeutic use
Cholestasis - complications
Cholestasis - drug therapy
Cholestasis - pathology
Disease Models, Animal -
Epithelial Cells - drug effects
Epithelial Cells - metabolism
Hepatocytes - drug effects
Hepatocytes - metabolism
Humans -
Jaundice, Obstructive - complications
Jaundice, Obstructive - drug therapy
Jaundice, Obstructive - pathology
Kidney Tubules - pathology
Liver - cytology
Liver - drug effects
Liver - metabolism
Liver - pathology
Renal Elimination -
Ursodeoxycholic Acid - analogs & derivatives
Ursodeoxycholic Acid - pharmacology
Ursodeoxycholic Acid - therapeutic use

Find related publications in this database (Keywords)
Cholemic nephropathy
Bile cast nephropathy
Bile acids
Liver cirrhosis
Acute kidney injury
© Meduni Graz Impressum