Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Trummer, C; Schwetz, V; Pandis, M; Grübler, MR; Verheyen, N; Gaksch, M; Zittermann, A; März, W; Aberer, F; Lang, A; Friedl, C; Tomaschitz, A; Obermayer-Pietsch, B; Pieber, TR; Pilz, S; Treiber, G.
Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial.
Nutrients. 2017; 9(6):
Doi: 10.3390/nu9060623
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- Führende Autor*innen der Med Uni Graz
- Theiler-Schwetz Verena
- Trummer Christian
- Co-Autor*innen der Med Uni Graz
- Aberer Felix
- Grübler Martin
- Keppel Martin
- Lackner Claudia
- März Winfried
- Obermayer-Pietsch Barbara
- Pandis Marlene
- Pieber Thomas
- Pilz Stefan
- Tomaschitz Andreas
- Treiber Gerlies
- Verheyen Nicolas Dominik
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- Abstract:
- Increasing evidence suggests a possible interaction between vitamin D and insulin-like growth factor-1 (IGF-1). We aimed to investigate effects of vitamin D supplementation on IGF-1 (primary outcome) and calcitriol (1,25(OH)₂D) concentrations (secondary outcome). This is a post-hoc analysis of the Styrian Vitamin D Hypertension Trial-a single-center, double-blind, randomized, placebo-controlled trial (RCT) conducted from 2011 to 2014 at the Medical University of Graz, Austria. Two-hundred subjects with arterial hypertension and 25(OH)D concentrations <30 ng/mL were randomized to either receive 2800 IU of vitamin D daily or placebo for eight weeks. A total of 175 participants (mean ± standard deviation age, 60 ± 11 years; 49% women) with available IGF-1 concentrations were included in the present analysis. At baseline, IGF-1 concentrations were significantly correlated with 1,25(OH)₂D (r = 0.21; p = 0.005) but not with 25(OH)D (r = -0.008; p = 0.91). In the RCT, vitamin D had no significant effect on IGF-1 (mean treatment effect 3.1; 95% confidence interval -5.6 to 11.9 ng/mL; p = 0.48), but it increased 1,25(OH)₂D concentrations (mean treatment effect 9.2; 95% confidence interval 4.4 to 13.9 pg/mL; p ≤ 0.001). In this RCT, in hypertensive patients with low 25(OH)D concentrations, there was no significant effect of vitamin D supplementation on IGF-1 concentrations. However, we observed a cross-sectional correlation between 1,25(OH)₂D and IGF-1 and an increase of 1,25(OH)₂D after vitamin D supplementation.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Calcitriol - blood, metabolism
- Double-Blind Method - administration & dosage
- Female - administration & dosage
- Gene Expression Regulation - drug effects
- Humans - administration & dosage
- Insulin-Like Growth Factor I - metabolism
- Male - administration & dosage
- Middle Aged - administration & dosage
- Vitamin D - administration & dosage, pharmacology
- Find related publications in this database (Keywords)
- insulin-like growth factor-1
- calcitriol
- vitamin D supplementation