Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Goblirsch, M; Richtig, G; Slaby, O; Berindan-Neagoe, I; Gerger, A; Pichler, M.
MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy.
Pharmacogenomics. 2017; 18(10):1027-1038 Doi: 10.2217/pgs-2017-0004
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Führende Autor*innen der Med Uni Graz
Pichler Martin
Richtig Georg
Co-Autor*innen der Med Uni Graz
Gerger Armin

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Colorectal cancer is a common type of malignant disease with high rates of morbidity and mortality. Although treatment options have been expanded over the last years, the mainstay of curative treatment remains surgical removal of the tumor-bearing organ. Systemic treatment options include classic cytotoxic drugs as well as some biological agents. Noncoding RNAs are an evolving field in cancer diagnosis, prognosis and possible treatment. Noncoding miRNAs are small molecules with huge impact on gene expression. They have been a substantial part of cancer research for more than a decade. In this review article, the current knowledge of miRNAs and colorectal cancer diagnosis, prognosis and novel or evolving therapeutic concepts are discussed. Examples of how miRNAs might change the management of the disease will be described.
Find related publications in this database (using NLM MeSH Indexing)
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Biomarkers, Tumor - genetics
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - genetics
Gene Expression Regulation, Neoplastic -
Humans -
MicroRNAs - genetics
Molecular Targeted Therapy -
Prognosis -

Find related publications in this database (Keywords)
colorectal cancer
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