Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Panzuto, F; Merola, E; Pavel, ME; Rinke, A; Kump, P; Partelli, S; Rinzivillo, M; Rodriguez-Laval, V; Pape, UF; Lipp, R; Gress, T; Wiedenmann, B; Falconi, M; Delle Fave, G.
Stage IV Gastro-Entero-Pancreatic Neuroendocrine Neoplasms: A Risk Score to Predict Clinical Outcome.
Oncologist. 2017; 22(4):409-415 Doi: 10.1634/theoncologist.2016-0351 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Co-Autor*innen der Med Uni Graz
Kump Patrizia
Lipp Rainer

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Several risk factors predict clinical outcome in gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs); however, the impact of their combination has not been investigated so far. A retrospective analysis of stage IV GEP-NENs was performed. Multivariate analysis for progression of disease (PD) was performed by Cox proportional hazards method to obtain a risk score. Area under the curve obtained by receiver operating characteristic analysis was used to assess the score performance. Progression-free survival analysis was performed by Kaplan-Meier method. Two hundred eighty-three stage IV GEP-NENs were evaluated, including 93 grade 1 neuroendocrine tumors (32.9%), 153 grade 2 neuroendocrine tumors (54%), and 37 grade 3 neuroendocrine carcinomas (13.1%). Independent risk factors for PD were Ki67, proportion of metastatic liver involvement, and presence of extra-abdominal metastases. The risk score was calculated as follows: (0.025 × Ki67) + [(0 if no liver metastases or liver involvement <25%) OR (0.405 if liver involvement 25%-50%) OR (0.462 if liver involvement >50%)] + [(0 if no extra-abdominal metastases) OR (0.528 if extra-abdominal metastases present)]. The risk score accuracy to predict PD was superior compared with the G grading system (area under the curve: 0.705 and 0.622, respectively). Three subgroups of patients with low, intermediate, and high risk of PD according to risk score were identified, median progression-free survival being 26 months, 19 months, and 12 months, respectively. In stage IV GEP-NENs, a risk score able to predict PD was obtained by combining Ki67, proportion of metastatic liver involvement, and presence of extra-abdominal metastases. The score may help to discriminate patients with different progression risk level to plan tailored therapeutic approaches and follow-up programs. The Oncologist 2017;22:409-415Implications for Practice: Clinical outcome of patients with advanced gastro-entero-pancreatic neuroendocrine neoplasms is affected by several risk factors, including the proliferative index Ki67, extension of liver metastases, and the presence of distant extra-abdominal lesions. A risk score that combines these variables may help physicians dealing with these diseases to plan the optimal therapeutic approach and follow-up program. © AlphaMed Press 2017.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Disease Progression -
Disease-Free Survival -
Female -
Humans -
Intestinal Neoplasms - diagnosis
Intestinal Neoplasms - epidemiology
Intestinal Neoplasms - pathology
Male -
Middle Aged -
Neoplasm Metastasis -
Neoplasm Staging -
Neuroendocrine Tumors - diagnosis
Neuroendocrine Tumors - epidemiology
Neuroendocrine Tumors - pathology
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - pathology
Proportional Hazards Models -
Risk Factors -
Stomach Neoplasms - diagnosis
Stomach Neoplasms - epidemiology
Stomach Neoplasms - pathology

Find related publications in this database (Keywords)
Neuroendocrine tumors
Risk score
Disease progression
© Med Uni Graz Impressum